Outgrowth by fin motor axons in wildtype and a finless mutant of the Japanese medaka fish.
Outgrowth by fin motor axons in wildtype and a finless mutant of the Japanese medaka fish.
复制标题
日本青鳉鱼野生型和无鳍突变体中鳍运动轴突的生长。
DOI：
10.1016/0012-1606(91)90445-9
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发表时间：
1991
影响因子：
2.7
通讯作者：
Kuwada,JY
中科院分区：
文献类型：
--
作者：
Okamoto,H;Kuwada,JY
研究了日本青鳉鱼（Oryzias latipes）发育中胸鳍的运动轴突的生长，在野生型胚胎和成年无胸鳍的无胸鳍（pl）突变体中进行了研究。在胚胎发生后期，胸鳍是一个简单的肢体，包含两个拮抗肌，由来自前四个脊髓节段（S1-4）的假定运动神经元支配。胸鳍由位于 S1 和 S2 的鳍芽发育而来，以 S1 和 S2 之间的边界为中心，与其他肢体一样，最早的分化迹象之一是顶端外胚层脊 (AER)。当 AER 形成良好时，假定的运动神经元的生长锥已到达鳍芽的基部，并在从脊髓中出现时通过向鳍芽延伸而形成神经丛。这在同质排列的轴肌的腹侧表面上尤其明显。例如，来自 S2 的生长锥沿对角线方向（前侧和侧向）朝向鳍芽延伸。可以解释运动生长模式的一种假设是，生长锥可能通过长距离提示而被吸引到鳍芽的基部。通过检查鳍芽中节段神经的生长来检验这一假设，其中鳍芽在 AER 最初出现后在发育早期停止。 Inpl，来自S1-4的神经在异常鳍芽的基部汇聚形成神经丛，但生长模式与野生型不同，其方式与鳍芽吸引节段神经的能力减弱一致。
The outgrowth of motor axons to the developing pectoral fin of the Japanese medaka fish (Oryzias latipes) was investigated both in wildtype embryos and in thepectoral finless(pl) mutants in which adults are missing pectoral fins. Late in embryogenesis the pectoral fin is a simple limb which contains two antagonist muscles which are innervated by presumptive motor neurons from the first four spinal segments (S1–4). The pectoral fin develops from a fin bud located in S1 and S2 centered on the border between S1 and S2 and, as with other limbs, one of the earliest signs of differentiation is the apical ectodermal ridge (AER). By the time the AER is well formed the growth cones of the presumptive motor neurons have reached the base of the fin bud and formed a plexus by extending toward the fin bud upon emergence from the spinal cord. This is especially evident on the ventral surface of the metamerically arranged axial muscles. For example, growth cones from S2 extend in a diagonal direction (both anterior and lateral) towards the fin bud. One hypothesis which can account for the pattern of motor outgrowth is that growth cones are attracted to the base of the fin bud, perhaps via a long distance cue. This hypothesis was tested by examining outgrowth of segmental nerves inplembryos in which the fin buds arrest early in development following the initial appearance of the AER. Inpl, nerves from S1–4 converged to form a plexus at the base of the abnormal fin bud, but the pattern of outgrowth varied from wildtype in a way consistent with a diminished capacity of the fin bud to attract segmental nerves to it.
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影响因子：
2.5
作者：
BENNETT, MR;DAVEY, DF;UEBEL, KE
通讯作者：
UEBEL, KE
日本青鳉鱼鳍芽消融和异位鳍芽后胸鳍神经的改变。
影响因子：
2.7
作者：
Okamoto,H;Kuwada,JY
通讯作者：
Kuwada,JY
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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