Green Synthesis, Characterizations of Zinc Oxide Nanoparticles from Aqueous Leaf Extract of Tridax procumbens Linn. and Assessment of their Anti-Hyperglycemic Activity in Streptozoticin-Induced Diabetic Rats.
Green Synthesis, Characterizations of Zinc Oxide Nanoparticles from Aqueous Leaf Extract of Tridax procumbens Linn. and Assessment of their Anti-Hyperglycemic Activity in Streptozoticin-Induced Diabetic Rats.
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DOI：
10.3390/ma15228202
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发表时间：
2022-11-18
期刊：
影响因子：
--
通讯作者：
Kavitha K
中科院分区：
文献类型：
--
作者：
Ahmed SS;Alqahtani AM;Alqahtani T;Alamri AH;Menaa F;Mani RK;D R B;Kavitha K
在本文中，氧化锌纳米颗粒（ZnO NP）是从Tridax procumbens含水叶提取物（TPE）绿色合成的，并进行物理表征（例如，傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM））和生物学（测试其抗糖尿病活性）。TPE和TPE衍生的ZnO纳米颗粒的抗糖尿病活性已经在链脲佐菌素（STZ）诱导的糖尿病大鼠模型中进行。用单次腹膜内剂量的葡萄糖类似物STZ（55 mg/Kg）诱导糖尿病（DM），已知该葡萄糖类似物STZ对产生胰腺胰岛素的β细胞特别有毒。TPE和TPE衍生的ZnO NP分别以100和200 mg/Kg口服给药糖尿病大鼠，每天一次，持续21天。使用标准抗糖尿病药物格列本脲作为对照，剂量为10 mg/Kg。对各种参数进行了研究，包括体重（bw）变化、糖化血红蛋白（HbA 1c）、脂血、糖化血红蛋白（HbA 1c）以及大鼠肝脏和胰腺的组织病理学变化。TPE介导的NP是小的、球形的、稳定的和均匀的。与TPE相比，以及与格列本脲相比，TPE衍生的ZnO NP在较小程度上显著降低血糖水平（p < 0.05），并且以剂量依赖性方式降低血糖水平，同时防止体重减轻。此外，还注意到TPE衍生的ZnO NP对脂质谱和糖化血红蛋白两者的积极益处。组织病理学评估表明，合成的TPE衍生的ZnO纳米颗粒是安全的，无毒的，和生物相容性。在200 mg/Kg/天时，TPE衍生的ZnO NP比在100 mg/Kg/天时具有更显著的低血糖反应。因此，在这个首次报道的实验环境中，从Tridax procumbens的叶提取物生物合成的ZnO NPs比TPE和格列本脲发挥更有效的抗糖尿病活性。我们的结论是，这种绿色制备的纳米材料可能是一种有前途的替代或补充（辅助）治疗，至少对目前印度的传统医学系统。在人群中提示转化结果以确定这些NP的功效。
Herein, zinc oxide nanoparticles (ZnO NPs) were greenly synthesized from Tridax procumbens aqueous leaf extract (TPE) and characterized physically (e.g., Fourier-transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM)) and biologically (test of their anti-diabetic activity). Anti-diabetic activities of TPE and TPE-derived ZnO NPs have been carried out in a streptozotocin (STZ)—induced diabetic rat model. Diabetes mellitus (DM) was induced with a single intraperitoneal dosage of the glucose analogue STZ (55 mg/Kg) known to be particularly toxic to pancreatic insulin-producing beta-cells. TPE and TPE-derived ZnO NPs were administered orally, once every day for 21 days in diabetic rats, at 100 and 200 mg/Kg, respectively. The standard antidiabetic medication, glibenclamide, was used as a control at a dose of 10 mg/Kg. Various parameters were investigated, including bodyweight (bw) variations, glycemia, lipidaemia, glycated hemoglobin (HbA1c), and histopathological alterations in the rat’s liver and pancreas. The TPE-mediated NPs were small, spherical, stable, and uniform. Compared to TPE and, to a lesser extent, glibenclamide, TPE-derived ZnO NPs lowered blood glucose levels considerably (p < 0.05) and in a dose-dependent manner while preventing body weight loss. Further, positive benefits for both the lipid profile and glycated hemoglobin were also noticed with TPE-derived ZnO NPs. The histopathological assessment revealed that synthesized TPE-derived ZnO NPs are safe, non-toxic, and biocompatible. At 200 mg/Kg/day, TPE-derived ZnO NPs had a more substantial hypoglycemic response than at 100 mg/Kg/day. Thus, in this first reported experimental setting, ZnO NPs biosynthesized from the leaf extract of Tridax procumbens exert more potent anti-diabetic activity than TPE and glibenclamide. We conclude that such a greenly prepared nanomaterial may be a promising alternative or complementary (adjuvant) therapy, at least to the current Indian’s traditional medicine system. Translational findings are prompted in human populations to determine the efficacy of these NPs.
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影响因子：
0.2
作者：
Parasuraman S;Raveendran R;Kesavan R
通讯作者：
Kesavan R
DOI：
10.4103/0976-0105.121655
发表时间：
2013-09
期刊：
Journal of basic and clinical pharmacy
影响因子：
--
作者：
Petchi RR;Parasuraman S;Vijaya C
通讯作者：
Vijaya C
DOI：
10.3390/bioengineering7040129
发表时间：
2020-10-16
期刊：
Bioengineering (Basel, Switzerland)
影响因子：
--
作者：
Uzair B;Liaqat A;Iqbal H;Menaa B;Razzaq A;Thiripuranathar G;Fatima Rana N;Menaa F
通讯作者：
Menaa F
影响因子：
5.4
作者：
Madic, Visnja;Petrovic, Aleksandra;Vasiljevic, Perica
通讯作者：
Vasiljevic, Perica
影响因子：
3.4
作者：
Bairagi, Ujjawal;Mittal, Pooja;Mishra, Brahmeshwar
通讯作者：
Mishra, Brahmeshwar