Prolonged dopamine signalling in striatum signals proximity and value of distant rewards.
Prolonged dopamine signalling in striatum signals proximity and value of distant rewards.
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对未来奖励事件的预测对行为有很大的影响。含有多巴胺的神经元的相位峰活动，以及纹状体中相应的多巴胺瞬变，被认为是这些预测的基础，编码了积极和消极的奖励预测错误。然而，许多行为都指向遥远的目标，而短暂的信号可能无法提供持续的驱动力。在这里，我们报道了一种新颖的、扩展的奖赏预测模式-纹状体中的多巴胺信号，当大鼠向远处的目标移动时，纹状体中出现了这种信号。这些用快速扫描循环伏安法(FSCV)检测到的多巴胺信号，随着动物通过迷宫到达遥远的奖赏而逐渐增加或减少，而不是具有阶段性或稳定的紧张性轮廓。这些多巴胺的增加(斜率)随着奖励的距离和大小而灵活调整。在学习过程中，这些多巴胺信号表现出对不同位置目标的空间偏好，并且很容易改变大小，以反映远处奖励的值的变化。这种长时间的多巴胺信号可以提供持续的动机驱动，这是一种对正常行为可能很重要的控制机制，可能会在一系列神经和神经精神障碍中受损。
Predictions about future rewarding events have a powerful influence on behaviour. The phasic spike activity of dopamine-containing neurons, and corresponding dopamine transients in the striatum, are thought to underlie these predictions, encoding positive and negative reward prediction errors. Many behaviours, however, are directed toward distant goals, for which transient signals might fail to provide sustained drive. Here we report a novel, extended mode of reward-predictive dopamine signalling in the striatum that emerged as rats moved toward distant goals. These dopamine signals, which were detected with fast-scan cyclic voltammetry (FSCV), gradually increased or--in rare instances--decreased as the animals navigated mazes to reach remote rewards, rather than having phasic or steady tonic profiles. These dopamine increases (ramps) scaled flexibly with both the distance and size of the rewards. During learning, these dopamine signals exhibited spatial preferences for goals in different locations and readily changed in magnitude to reflect changing values of the distant rewards. Such prolonged dopamine signalling could provide sustained motivational drive, a control mechanism that may be important for normal behaviour and that can be impaired in a range of neurologic and neuropsychiatric disorders.
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
2.7
作者：
WHISHAW, IQ;DUNNETT, SB
通讯作者：
DUNNETT, SB
影响因子：
64.8
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
通讯作者：
Graybiel, AM
影响因子：
48
作者：
Clark, Jeremy J.;Sandberg, Stefan G.;Wanat, Matthew J.;Gan, Jerylin O.;Horne, Eric A.;Hart, Andrew S.;Akers, Christina A.;Parker, Jones G.;Willuhn, Ingo;Martinez, Vicente;Evans, Scott B.;Stella, Nephi;Phillips, Paul E. M.
通讯作者：
Phillips, Paul E. M.