Using an Engineered Galvanic Redox System to Generate Positive Surface Potentials that Promote Osteogenic Functions.
Using an Engineered Galvanic Redox System to Generate Positive Surface Potentials that Promote Osteogenic Functions.
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DOI：
10.1021/acsami.8b02798
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发表时间：
2018-05-09
影响因子：
9.5
通讯作者：
Soo C
中科院分区：
文献类型：
--
作者：
Zhang Y;Zheng Z;Yu M;Hsu C;Berthiaume EA;Pan H;Zhang X;Stieg AZ;Wu B;Wang H;Ting K;Soo C
矫形和正畸植入物的成功骨整合依赖于骨生成和植入物-组织界面上的细菌污染之间的竞争。以前，通过利用银纳米颗粒（AgNP）的高度相互作用能力，我们使用AgNP/聚（DL-乳酸-共-乙醇酸）（PLGA）涂层有效地将抗菌作用引入金属植入物材料。虽然电力已被证明可以促进骨生成，但创造能够利用这些力来诱导骨再生的实用材料和装置仍然具有挑战性。在这里，我们应用电化学还原-氧化（氧化还原）原理来设计AgNPs和316L不锈钢合金（316L-SA）之间的纳米级电化学氧化还原系统。通过扫描电子显微镜、能量色散X射线光谱仪、原子力显微镜、Kelvin探针力显微镜和接触角测量表征，产量AgNP/PLGA涂覆的316L-SA（SNPSA）材料的表面性质呈现出显著增加的正表面电位、亲水性、表面极性分数和表面电子接受/供给指数。重要的是，除了其杀菌特性外，SNPSA的表面还通过促进种植体周围骨生长表现出新型成骨生物活性。这是第一份报告，描述了一个通常有害的电化学氧化还原反应转化为生物有益的功能，对生物医学金属材料。总的来说，这项研究详细介绍了一种创新的策略，设计多功能的生物材料，使用受控的电化学氧化还原反应，在材料开发和临床实践中具有广泛的应用。
Successful osseointegration of orthopaedic and orthodontic implants is dependent on a competition between osteogenesis and bacterial contamination on the implant–tissue interface. Previously, by taking advantage of the highly interactive capabilities of silver nanoparticles (AgNPs), we effectively introduced an antimicrobial effect to metal implant materials using an AgNP/poly(DL-lactic-co-glycolic acid) (PLGA) coating. Although electrical forces have been shown to promote osteo-genesis, creating practical materials and devices capable of harnessing these forces to induce bone regeneration remains challenging. Here, we applied galvanic reduction–oxidation (redox) principles to engineer a nanoscale galvanic redox system between AgNPs and 316L stainless steel alloy (316L-SA). Characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy, Kelvin probe force microscopy, and contact angle measurement, the surface properties of the yield AgNP/PLGA-coated 316L-SA (SNPSA) material presented a significantly increased positive surface potential, hydrophilicity, surface fractional polarity, and surface electron accepting/donating index. Importantly, in addition to its bactericidal property, SNPSA’s surface demonstrated a novel osteogenic bioactivity by promoting peri-implant bone growth. This is the first report describing the conversion of a normally deleterious galvanic redox reaction into a biologically beneficial function on a biomedical metal material. Overall, this study details an innovative strategy to design multifunctional biomaterials using a controlled galvanic redox reaction, which has broad applications in material development and clinical practice.
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影响因子：
1
作者：
Kuzyk PR;Schemitsch EH
通讯作者：
Schemitsch EH
DOI：
10.3390/ma10040406
发表时间：
2017-04-13
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Alcántara J;Fuente D;Chico B;Simancas J;Díaz I;Morcillo M
通讯作者：
Morcillo M
影响因子：
14
作者：
Liu, Yi;Zheng, Zhong;Soo, Chia
通讯作者：
Soo, Chia
影响因子：
29.4
作者：
Abidian, MR;Kim, DH;Martin, DC
通讯作者：
Martin, DC
影响因子：
9
作者：
Nadeem, Danish;Smith, Carol-Anne;Su, Bo
通讯作者：
Su, Bo