Comparative analysis of whole saliva proteomes for the screening of biomarkers for oral lichen planus
Comparative analysis of whole saliva proteomes for the screening of biomarkers for oral lichen planus
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全唾液蛋白质组的比较分析用于筛选口腔扁平苔藓的生物标志物
DOI：
10.1007/s00011-006-5145-8
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发表时间：
2006-07
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
目的应用蛋白质组学技术筛选口腔扁平苔藓（oral lichen planus，OLP）患者全唾液中可能的生物标志物。结果共鉴定出31个蛋白质点，代表14种蛋白质，鉴定出OLP和对照之间丰度的至少两倍差异。结论尿激肽释放酶原和短腭、肺和鼻上皮癌相关蛋白（PLK）可能是参与OLP炎症和免疫反应的新的生物标志物。
ObjectiveTo screen possible biomarkers in whole saliva from oral lichen planus (OLP) patients by proteomic techniques.MethodsTwo-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were applied to whole saliva of OLP patients and controls, and the differential protein components were analyzed with peptide mass fingerprinting and database searching.ResultsA total of 31 protein spots representing 14 proteins with at least two-fold difference in abundance between OLP and controls were identified. Among these, the expression of urinary prokallikrein was increased while short palate, lung and nasal epithelium carcinoma associated protein (PLUNC) was decreased in all samples of OLP.ConclusionsUrinary prokallikrein and PLUNC may be the new biomarkers which play a role in inflammation and immune response of OLP.
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DOI：
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发表时间：
1998-12
期刊：
The Journal of rheumatology
影响因子：
--
作者：
C. C. Hernández-C.;E. Donadi;M. L. Reis
通讯作者：
C. C. Hernández-C.;E. Donadi;M. L. Reis
影响因子：
2.9
作者：
N. Kusukawa;M. Ostrovsky;M. Garner
通讯作者：
N. Kusukawa;M. Ostrovsky;M. Garner
影响因子：
3.3
作者：
Khan, A;Farah, CS;Sugerman, PB
通讯作者：
Sugerman, PB
DOI：
10.1016/j.bbapap.2004.01.001
发表时间：
2004-06-01
影响因子：
3.2
作者：
Ghafouri, B;Kihlström, E;Lindahl, M
通讯作者：
Lindahl, M
影响因子：
8.6
作者：
Rhodus, NL;Cheng, B;Ondrey, F
通讯作者：
Ondrey, F