Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study.
Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study.
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DOI：
10.1016/j.jad.2014.03.048
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发表时间：
2014-08
影响因子：
6.6
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Shu H;Yuan Y;Xie C;Bai F;You J;Li L;Li SJ;Zhang Z
载脂蛋白 E (APOE) ε4 等位基因和老年抑郁症病史已被证实是阿尔茨海默病 (AD) 的危险因素。这两个因素的共存可能会显着增加非痴呆老年人认知障碍的风险。然而，这种关联的神经基础仍不清楚。招募了 31 名缓解老年抑郁症 (RGD) 患者和 29 名认知正常受试者，并接受了静息态功能 MRI 扫描。根据 APOE 基因型，将他们进一步分为四组。采用基于海马种子的网络分析和双向协方差因子分析来检测RGD和APOE ε4等位基因对海马功能连接（HFC）网络的主效应和交互效应。应用偏相关分析来检验这些改变的 HFC 网络的认知意义。 RGD 患者的 HFC 网络在背侧额叶区域减少，在右侧颞枕区域增加。对于 APOE ε4 携带者，HFC 网络主要在内侧前额叶区域减少，在双侧岛叶增强。此外，当两种因素共存时，背侧前扣带皮层的左侧 HFC 网络显着破坏，躯体运动和枕叶区域的左侧 HFC 网络显着增加。重要的是，网络改变的程度与 RGD 患者和 APOE ε4 携带者的认知表现较差有关。样本量小可能会限制我们研究结果的普遍性。 RGD 和 APOE ε4 等位基因及其相互作用与不平衡的 HFC 网络有关，这可能会导致 AD 高风险受试者的认知能力下降。
Apolipoprotein E (APOE) ε4 allele and a history of geriatric depression are confirmed risk factors of Alzheimer’s disease (AD). Coexistence of both factors could notably enhance the risk of cognitive impairment in nondemented elderly. However, neural basis of the association remains unclear. Thirty-one remitted geriatric depression (RGD) patients and 29 cognitively normal subjects were recruited and underwent resting-state functional MRI scans. They were further divided into four groups according to their APOE genotypes. Hippocampal seed-based network analysis and two-way factorial analysis of covariance were employed to detect the main effects and interactive effects of RGD and APOE ε4 allele on the hippocampal functional connectivity (HFC) networks. Partial correlation analysis was applied to examine the cognitive significance of these altered HFC networks. The HFC networks of RGD patients were decreased in the dorsal frontal and increased in the right temporal-occipital regions. For APOE ε4 carriers, the HFC networks were reduced primarily in medial prefrontal regions and enhanced in the bilateral insula. Additionally, when both factors coexisted, the left HFC network was significantly disrupted in the dorsal anterior cingulate cortex and increased in somatomotor and occipital regions. Importantly, the extent of network alterations was linked to inferior cognitive performances in RGD patients and APOE ε4 carriers. The small sample size may limit the generalizability of our findings. RGD and APOE ε4 allele, and their interaction, are associated with the imbalanced HFC network, which may contribute to cognitive deterioration for subjects with a high risk of AD.
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影响因子：
5.7
作者：
Qiu A;Taylor WD;Zhao Z;MacFall JR;Miller MI;Key CR;Payne ME;Steffens DC;Krishnan KR
通讯作者：
Krishnan KR
影响因子：
3.7
作者：
Bai F;Xie C;Watson DR;Shi Y;Yuan Y;Wang Y;Yue C;Teng Y;Wu D;Zhang Z
通讯作者：
Zhang Z
影响因子：
3.7
作者：
Bai F;Watson DR;Shi Y;Wang Y;Yue C;YuhuanTeng;Wu D;Yuan Y;Zhang Z
通讯作者：
Zhang Z
影响因子：
7.2
作者：
Alexopoulos, GS
通讯作者：
Alexopoulos, GS
DOI：
10.1093/gerona/gln013
发表时间：
2009-02-01
影响因子：
5.1
作者：
Niti, Mathew;Yap, Keng-Bee;Ng, Tze-Pin
通讯作者：
Ng, Tze-Pin