The role of periosteum in cartilage repair.
The role of periosteum in cartilage repair.
复制标题
骨膜在软骨修复中的作用。
DOI：
10.1097/00003086-200110001-00019
复制
发表时间：
2001
影响因子：
4.2
通讯作者：
J. Fitzsimmons
中科院分区：
文献类型：
--
作者：
S. O’Driscoll;J. Fitzsimmons
Periosteum, which can be grown in cell and whole tissue cultures, may meet one or more of the three prerequisites for tissue engineered cartilage repair. Periosteum contains pluripotential mesenchymal stem cells with the potential to form either cartilage or bone. Because it can be transplanted as a whole tissue, it can serve as its own scaffold or a matrix onto which other cells and/or growth factors can be adhered. Finally, it produces bioactive factors that are known to be chondrogenic. The chondrocyte precursor cells reside in the cambium layer. These vary in total density and volume with age and in different donor sites. The advantages of whole tissue periosteal transplants for cartilage repair include the fact that this tissue meets the three primary requirements for tissue engineering: a source of cells, a scaffold for delivering and retaining them, and a source of local growth factors. Many growth factors that regulate chondrocytes and cartilage development are synthesized by periosteum in conditions conducive to chondrogenesis. These include transforming growth factor-beta 1, insulinlike growth factor-1, growth and differentiation factor-5, bone morphogenetic protein-2, integrins, and the receptors for these molecules. By additional study of the molecular events in periosteal chondrogenesis, it may be possible to optimize its capacity for articular cartilage repair.
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使用肋骨软骨膜自体移植物修复全层关节软骨缺损的新软骨的形态学和生物力学评估：一项长期研究。
影响因子：
2.4
作者：
Kwan,MK;Coutts,RD;Woo,SL;Field,FP
通讯作者：
Field,FP
DOI：
10.1002/jbm.820290915
发表时间：
1995-09-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
CHU, CR;COUTTS, RD;AMIEL, D
通讯作者：
AMIEL, D
DOI：
10.2106/00004623-198567060-00013
发表时间：
1985-01-01
影响因子：
5.3
作者：
AMIEL, D;COUTTS, RD;AKESON, WH
通讯作者：
AKESON, WH
DOI：
10.1002/jbm.820250305
发表时间：
1991-03
期刊：
Journal of biomedical materials research
影响因子：
--
作者：
Herbert P. von Schroeder;Michael K. Kwan;David Amiel;Richard D. Coutts
通讯作者：
Herbert P. von Schroeder;Michael K. Kwan;David Amiel;Richard D. Coutts
关节缺损中肋骨软骨膜移植物产生的新软骨组织中的胶原类型——一种快速半定量方法。
DOI：
10.1016/s0174-173x(85)80022-4
发表时间：
1985
期刊：
Collagen and related research
影响因子：
--
作者：
Amiel,D;Harwood,FL;Abel,MF;Akeson,WH
通讯作者：
Akeson,WH