Morphological and biomechanical evaluations of neocartilage from the repair of full-thickness articular cartilage defects using rib perichondrium autografts: a long-term study.
Morphological and biomechanical evaluations of neocartilage from the repair of full-thickness articular cartilage defects using rib perichondrium autografts: a long-term study.
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使用肋骨软骨膜自体移植物修复全层关节软骨缺损的新软骨的形态学和生物力学评估：一项长期研究。
DOI：
10.1016/0021-9290(89)90076-6
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发表时间：
1989
影响因子：
2.4
通讯作者：
Field,FP
中科院分区：
文献类型：
--
作者：
Kwan,MK;Coutts,RD;Woo,SL;Field,FP
将自体肋骨软骨膜移植到兔膝关节股骨髁全层软骨缺损处，观察1年后再生的软骨。研究了两种术后治疗效果，一种是自由活动（CAGE），另一种是将手术膝关节放置在连续被动运动机器上2周（8 h/d-1，5 d/周-1），然后进行笼式活动（PM）。在术后6、12、26和52周处死动物。术后第52周，新生软骨与周围软骨外观相似，与周围组织融合良好。新生长的组织在形态上类似于正常的透明关节软骨。CAGE组和PM组新生软骨的动态剪切模量随术后愈合时间的延长而显著增加（p<0.05）。然而，两种治疗方式之间没有统计学差异（p>0.10），表明被动运动并没有增强软骨缺损的长期修复。这些结果支持我们的假设，即软骨膜自体移植物再生的新软骨随着时间的推移保持完整。
Neocartilage regenerated from rib perichondrium autografts implanted into full thickness cartilage defects made in the femoral condyle of rabbit knees were evaluated for periods up to 1 yr. Two postoperative treatment effects were studied, one withad lib.caged activity (CAGE) and the other with the operated knee placed on a continuous passive motion machine for 2 weeks (8 h day−1for 5 days week−1) followed by caged activity (PM). Animals were sacrificed at 6, 12, 26 and 52 weeks after surgery. The neocartilage was evaluated histologically and biomechanically and compared with the contralateral unoperated side.Visually, the neocartilage appeared to have an appearance similar to that of surrounding cartilage at 52 weeks, with an excellent degree of confluence with the neighboring tissue. The newly grown tissues were morphologically similar to normal hyaline articular cartilage. The dynamic shear moduli for the neocartilage from both the CAGE and PM groups significantly increased with postoperative healing time (p<0.05). However, there was no statistical difference between the two treatment modalities (p>0.10), indicating that the passive motion did not enhance the long-term repair of the cartilage defect. These results support our hypothesis that neocartilage regenerated from perichondrial autograft remains intact over time.
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影响因子：
15.9
作者：
P. Molé;L. B. Oscai;J. Holloszy
通讯作者：
J. Holloszy
支链α-酮酸对离体大鼠肝细胞代谢的影响。
影响因子：
4.8
作者：
E. Walajtys;K. Coll;J. Williamson
通讯作者：
J. Williamson
严重慢性非肾病性肾衰竭中的甘油三酯周转。
DOI：
10.1016/0026-0495(78)90130-0
发表时间：
1978
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
L. Verschoor;R. Lammers;J. Birkenhäger
通讯作者：
J. Birkenhäger
肉碱对维持性血液透析治疗的慢性尿毒症患者的降脂作用。
DOI：
10.1093/ajcn/33.7.1489
发表时间：
1980
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
G. Guarnieri;F. Ranieri;G. Toigo;A. Vasile;M. Ciman;V. Rizzoli;M. Moracchiello;L. Campanacci
通讯作者：
L. Campanacci
一种改进和简化的放射性同位素测定法，用于测定游离肉碱和酯化肉碱。
影响因子：
6.5
作者：
J. McGarry;D. W. Foster
通讯作者：
D. W. Foster