Gold nanoparticles: a revival in precious metal administration to patients.
Gold nanoparticles: a revival in precious metal administration to patients.
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DOI：
10.1021/nl202559p
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发表时间：
2011-10-12
期刊：
影响因子：
10.8
通讯作者：
Gambhir SS
中科院分区：
文献类型：
--
作者：
Thakor AS;Jokerst J;Zavaleta C;Massoud TF;Gambhir SS
黄金已被用作治疗多种风湿性疾病的药物，包括银屑病关节炎、青少年关节炎和盘状红斑狼疮。虽然金的使用在很大程度上已被新药所取代，但金纳米颗粒正在有效地用于基于实验室的临床诊断方法，同时在体内作为诊断显像剂或治疗剂显示出巨大的希望。由于这些原因，金纳米颗粒在不久的将来很有可能进入主流临床实践。因此，本文基于数十年来大量黄金用于治疗类风湿性关节炎的临床观察和实验，对其化学、药代动力学、生物分布、代谢和毒性等方面的研究进行综述。金纳米粒子的有利属性，如易于合成、功能化和形状控制，也突出了为什么金纳米粒子是一个有吸引力的目标，进一步发展和优化。本文还讨论了控制金纳米颗粒的大小和形状以减少潜在毒副作用的重要性。
Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis and discoid lupus erythematosus. Although the use of gold has been largely superseded by newer drugs, gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods whilst concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent. For these reasons, gold nanoparticles are therefore well placed to enter mainstream clinical practice in the near future. Hence, the present review summarizes the chemistry, pharmacokinetics, bio-distribution, metabolism and toxicity of bulk gold in humans based on decades of clinical observation and experiments in which gold was used to treat patients with rheumatoid arthritis. The beneficial attributes of gold nanoparticles, such as their ease of synthesis, functionalization and shape control are also highlighted demonstrating why gold nanoparticles are an attractive target for further development and optimization. The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed.
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DOI：
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发表时间：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY
影响因子：
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通讯作者：
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