Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels.
Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels.
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DOI：
10.1016/j.psyneuen.2012.07.010
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发表时间：
2013-04
影响因子：
3.7
通讯作者：
Alleva, Enrico
中科院分区：
文献类型：
--
作者：
Branchi, Igor;Curley, James P.;D'Andrea, Ivana;Cirulli, Francesca;Champagne, Frances A.;Alleva, Enrico
早期的社会环境对发展轨迹有着深远的影响。虽然贫困的早期环境可能会破坏获得适当的社会技能，个人的早期环境的不同组成部分在建立社会能力的具体作用尚未得到充分阐明。在这里，我们在小鼠中建立了一个异步的公共嵌套范式，以解开母亲的照顾和早期同伴互动对成年人的社会行为和神经系统的影响，据报道，参与社会互动的调节。异步公共筑巢包括三个母亲生产三天间隔，产生三组幼崽-老，中间和年轻-所有在一个巢从出生到断奶。我们对这些小鼠和在标准条件下饲养的第四组小鼠接受的母体和同伴互动的数量进行了评分。在成年期，四个实验组在社会互动测试中进行了社会行为调查，即在五次20分钟的日常遭遇中面对一个不熟悉的同种，以及催产素受体和BDNF水平。结果表明，只有暴露于高水平的母亲和同伴互动的个体表现出复杂的成人竞争能力，即及时显示社会地位的能力，以及海马体、额叶皮层和下丘脑中的高BDNF水平。相比之下，只有暴露于高水平的同伴互动的个体才表现出增强的成人亲和行为和增强的杏仁核中选定的催产素受体水平。总的来说，这些发现表明，早期与母亲和同龄人的互动独立地塑造了成年人社会行为和参与社会互动的神经系统的特定方面。
The early social environment has a profound impact on developmental trajectories. Although an impoverished early environment can undermine the acquisition of appropriate social skills, the specific role played by the different components of an individual’s early environment in building social competencies has not been fully elucidated. Here we setup an asynchronous communal nesting paradigm in mice to disentangle the influence of maternal care and early peer interactions on adult social behavior and neural systems reportedly involved in the regulation of social interactions. The asynchronous communal nesting consists of three mothers giving birth three days apart, generating three groups of pups -- the Old, the Middle and the Young – all raised in a single nest from birth to weaning. We scored the amount of maternal and peer interactions received by these mice and by a fourth group reared under standard conditions. At adulthood, the four experimental groups have been investigated for social behavior in a social interaction test, i.e. facing an unfamiliar conspecific during five 20-min daily encounters, and for oxytocin receptor and BDNF levels. Results show that only individuals exposed to high levels of both maternal and peer interactions demonstrated elaborate adult agonistic competencies, i.e. the ability to promptly display a social status, and high BDNF levels in the hippocampus, frontal cortex and hypothalamus. By contrast, only individuals exposed to high levels of peer interactions showed enhanced adult affiliative behavior and enhanced oxytocin receptor levels in selected nuclei of the amygdala. Overall these findings indicate that early interactions with mother and peers independently shape specific facets of adult social behavior and neural systems involved in social interaction.
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早期生活节目和神经发育障碍。
影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
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Nestler, Eric J.
影响因子：
3
作者：
Curley, James P.;Davidson, Stephanie;Champagne, Frances A.
通讯作者：
Champagne, Frances A.
影响因子：
3.7
作者：
Curley, J. P.;Jensen, C. L.;Mashoodh, R.;Champagne, F. A.
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Champagne, F. A.
影响因子：
3.3
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通讯作者：
Rios, M.
影响因子：
10.6
作者：
Branchi, Igor;D'Andrea, Ivana;Alleva, Enrico
通讯作者：
Alleva, Enrico