Transcriptomic Effects of Healthspan-Promoting Dietary Interventions: Current Evidence and Future Directions.
Transcriptomic Effects of Healthspan-Promoting Dietary Interventions: Current Evidence and Future Directions.
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DOI：
10.3389/fnut.2021.712129
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发表时间：
2021
影响因子：
5
通讯作者：
LaRocca TJ
中科院分区：
文献类型：
--
作者：
Wahl D;LaRocca TJ
衰老是大多数疾病的最大风险因素，包括心血管疾病、癌症、糖尿病和神经退行性疾病，但选择营养干预措施可能会大大降低这些疾病的风险。这些干预措施包括热量限制、间歇性禁食、蛋白质限制和减少某些氨基酸的摄入量。某些随意饮食，包括地中海饮食、芬兰预防认知障碍和残疾的老年干预研究以及冲绳饮食也促进健康衰老。有证据表明，这些饮食策略通过作用于生物“衰老标志”，特别是上游营养感应途径，来影响衰老和健康寿命。包括 RNA 测序（转录组学）在内的“组学”技术的最新进展，增加了我们对此类营养干预措施如何影响与衰老生物介质相关的基因表达的理解，主要是在临床前研究中。然而，这些影响是否也反映在人类转录组中，这可能为了解与衰老有关的其他下游/相关细胞过程提供见解，这是一个新兴话题。从广义上讲，对这些营养干预措施如何影响转录组的研究可能会为与衰老相关的途径提供新的见解，以及治疗与年龄相关的疾病和延长健康寿命的潜在目标。因此，这篇小型综述的目的是总结临床前模型和人类中关键饮食/营养干预措施的转录组学影响的已知信息，弥补文献中的空白，并提供对未来研究方向的见解。
Aging is the greatest risk factor most diseases, including cardiovascular disorders, cancers, diabetes, and neurodegeneration, but select nutritional interventions may profoundly reduce the risk for these conditions. These interventions include calorie restriction, intermittent fasting, protein restriction, and reducing intake of certain amino acids. Certain ad libitum diets, including the Mediterranean, Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, and Okinawan diets also promote healthy aging. Evidence indicates that these dietary strategies influence aging and healthspan by acting on the biological “hallmarks of aging” and especially upstream nutrient sensing pathways. Recent advances in “omics” technologies, including RNA-sequencing (transcriptomics), have increased our understanding of how such nutritional interventions may influence gene expression related to these biological mediators of aging, primarily in pre-clinical studies. However, whether these effects are also reflected in the human transcriptome, which may provide insight on other downstream/related cellular processes with aging, is an emerging topic. Broadly, the investigation of how these nutritional interventions influence the transcriptome may provide novel insight into pathways associated with aging, and potential targets to treat age-associated disease and increase healthspan. Therefore, the purpose of this mini review is to summarize what is known about the transcriptomic effects of key dietary/nutritional interventions in both pre-clinical models and humans, address gaps in the literature, and provide insight into future research directions.
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卡路里限制对基因表达中昼夜节律的影响是性别依赖性的。
影响因子：
4.6
作者：
Astafev AA;Patel SA;Kondratov RV
通讯作者：
Kondratov RV
DOI：
10.1093/gerona/glx101
发表时间：
2018-03-02
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Derous D;Mitchell SE;Green CL;Wang Y;Han JDJ;Chen L;Promislow DEL;Lusseau D;Douglas A;Speakman JR
通讯作者：
Speakman JR
影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
3.5
作者：
Elliott, R. M.;de Roos, B.;Johnson, I. T.
通讯作者：
Johnson, I. T.
翻转代谢开关：了解和应用禁食的健康益处。
DOI：
10.1002/oby.22065
发表时间：
2018-03
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Anton SD;Moehl K;Donahoo WT;Marosi K;Lee SA;Mainous AG 3rd;Leeuwenburgh C;Mattson MP
通讯作者：
Mattson MP