The effect of obesity on lung function.
The effect of obesity on lung function.
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DOI：
10.1080/17476348.2018.1506331
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发表时间：
2018-09
影响因子：
3.9
通讯作者：
Peters U
中科院分区：
文献类型：
--
作者：
Dixon AE;Peters U
肥胖是一种主要的流行病，许多肥胖患者患有呼吸道症状和疾病。肥胖对肺功能的总体影响是多因素的，与肥胖的机械和炎症方面有关。肥胖导致肺和胸壁的力学发生实质性变化，这些力学变化导致哮喘和哮喘样症状，如呼吸困难、喘息和气道高反应性。过度肥胖也与炎症细胞因子和免疫细胞的产生增加有关，这些细胞因子和免疫细胞也可能导致疾病。本文综述了肥胖与肺功能之间关系的文献，以及肥胖的机械和炎症效应如何导致肥胖成人和儿童肺力学和肺功能变化的研究。肥胖对呼吸功能有显著影响，这显著增加了呼吸系统疾病的负担。这些机械效应不容易用常规肺功能测试和BMI测量来量化。由脂肪组织产生的介质的变化可能也有助于改变肺功能，尽管到目前为止这还知之甚少。
There is a major epidemic of obesity, and many obese patients suffer with respiratory symptoms and disease. The overall impact of obesity on lung function is multi-factorial, related to mechanical and inflammatory aspects of obesity. Obesity causes substantial changes to the mechanics of the lungs and chest wall, these mechanical changes cause asthma and asthma-like symptoms such as dyspnea, wheeze and airway hyperresponsiveness. Excess adiposity is also associated with increased production of inflammatory cytokines and immune cells that may also lead to disease. This article reviews the literature addressing the relationship between obesity and lung function, and studies addressing how the mechanical and inflammatory effects of obesity might lead to changes in lung mechanics and pulmonary function in obese adults and children. Obesity has significant effects on respiratory function, which contribute significantly to the burden of respiratory disease. These mechanical effects are not readily quantified with conventional pulmonary function testing and measurement of BMI. Changes in mediators produced by adipose tissue likely also contribute to altered lung function, though as of yet this is poorly understood.
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影响因子：
4.8
作者：
De Blasio MJ;Boije M;Kempster SL;Smith GC;Charnock-Jones DS;Denyer A;Hughes A;Wooding FB;Blache D;Fowden AL;Forhead AJ
通讯作者：
Forhead AJ
影响因子：
10
作者：
Chinn, S;Jarvis, D;Burney, P
通讯作者：
Burney, P
影响因子：
9.6
作者：
COLLINS, LC;HOBERTY, PD;PEIRIS, AN
通讯作者：
PEIRIS, AN
影响因子：
5.8
作者：
Bulló, M;García-Lorda, P;Salas-Salvadó, J
通讯作者：
Salas-Salvadó, J
影响因子：
5.8
作者：
Bastard, JP;Jardel, C;Hainque, B
通讯作者：
Hainque, B