Increased aneurysm wall permeability colocalized with low wall shear stress in unruptured saccular intracranial aneurysm
Increased aneurysm wall permeability colocalized with low wall shear stress in unruptured saccular intracranial aneurysm
复制标题
未破裂囊状颅内动脉瘤中动脉瘤壁通透性增加与壁剪切应力低共定位
DOI：
10.1007/s00415-021-10869-z
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发表时间：
2021-11
影响因子：
6
通讯作者：
Ming
中科院分区：
文献类型：
--
作者：
Yajie Wang;Jie Sun;Rui Li;Peng Liu;Xian Liu;Jiansong Ji;Chunmiao Chen;Yu Chen;Haikun Qi;Yunduo Li;Longhui Zhang;Luqiong Jia;Fei Peng;Mingzhu Fu;Yishi Wang;Min Xu;Chunli Kong;Shuiwei Xia;Xiaole Wang;Le He;Qiang Zhang;Zhensen Chen;Aihua Liu;Youxiang Li;Ming
动脉瘤壁渗透性最近已成为动脉瘤壁重塑的体内标志物。我们试图在未破裂囊状颅内动脉瘤（IA）的基于区域的分析中研究4D-flow MRI得出的血流动力学力与DCE-MRI得出的动脉瘤壁渗透性之间的空间关系。我们对未破裂IA ≥ 5 mm的患者进行了4D-flow MRI和DCE-MRI，以测量血流动力学参数，包括壁面剪切应力（WSS）、振荡剪切指数（OSI）、WSS时间（WSSGt）和空间（WSSGs）梯度以及动脉瘤壁不同部分的动脉瘤壁渗透性（Ktranss），动脉瘤壁的不同部分由动脉瘤中心发出的均匀分布的径向线定义。评价了在扇形水平测量的Ktranss和血流动力学参数之间的空间关联。对31例患者进行了扫描，Ktranss不仅在动脉瘤之间不同，而且在动脉瘤内也表现出空间异质性。在所有159个节段中，较高的Ktranss与较低的WSS相关，这在斯皮尔曼相关性分析（rho =-0.18，p = 0.025）和使用广义估计方程的线性回归分析（回归系数=-0.33，p = 0.006）中均可见，以解释同一动脉瘤多个节段之间的相关性。在未破裂的囊状IA中，通过DCE-MRI显示的动脉瘤壁渗透性在空间上是不均匀的，并且通过4D-flow MRI显示与局部WSS相关。
Aneurysm wall permeability has recently emerged as an in vivo marker of aneurysm wall remodeling. We sought to study the spatial relationship between hemodynamic forces derived from 4D-flow MRI and aneurysm wall permeability by DCE-MRI in a region-based analysis of unruptured saccular intracranial aneurysms (IAs). We performed 4D-flow MRI and DCE-MRI on patients with unruptured IAs of ≥ 5 mm to measure hemodynamic parameters, including wall shear stress (WSS), oscillatory shear index (OSI), WSS temporal (WSSGt) and spatial (WSSGs) gradient, and aneurysm wall permeability (Ktrans) in different sectors of aneurysm wall defined by evenly distributed radial lines emitted from the aneurysm center. The spatial association betweenKtransand hemodynamic parameters measured at the sector level was evaluated. Thirty-one patients were scanned.Ktransnot only varied between aneurysms but also demonstrated spatial heterogeneity within an aneurysm. Among all 159 sectors, higherKtranswas associated with lower WSS, which was seen in both Spearman’s correlation analysis (rho = − 0.18,p= 0.025) and linear regression analysis using generalized estimating equation to account for correlations between multiple sectors of the same aneurysm (regression coefficient = − 0.33,p= 0.006). Aneurysm wall permeability by DCE-MRI was shown to be spatially heterogenous in unruptured saccular IAs and associated with local WSS by 4D-flow MRI.
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影响因子：
8.3
作者：
Miura, Yoichi;Ishida, Fujimaro;Taki, Waro
通讯作者：
Taki, Waro
影响因子：
3.3
作者：
Stalder, A. F.;Russe, M. F.;Markl, M.
通讯作者：
Markl, M.
影响因子：
4.1
作者：
Kadasi, Laith M.;Dent, Walter C.;Malek, Adel M.
通讯作者：
Malek, Adel M.
DOI：
--
发表时间：
2007-03
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
S. G. Wetzel;Stephan Meckel;Alex Frydrychowicz;L. Bonati;E. Radue;Klaus Scheffler;Jürgen Hennig;Michael Markl
通讯作者：
S. G. Wetzel;Stephan Meckel;Alex Frydrychowicz;L. Bonati;E. Radue;Klaus Scheffler;Jürgen Hennig;Michael Markl
影响因子：
4.4
作者：
H. Hawighorst;M. Libicher;M. Knopp;T. Moehler;G. Kauffmann;G. Kaick
通讯作者：
H. Hawighorst;M. Libicher;M. Knopp;T. Moehler;G. Kauffmann;G. Kaick