Metabolomics of Head and Neck Cancer: A Mini-Review.
Metabolomics of Head and Neck Cancer: A Mini-Review.
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DOI：
10.3389/fphys.2016.00526
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发表时间：
2016
影响因子：
4
通讯作者：
Kapila YL
中科院分区：
文献类型：
--
作者：
Shin JM;Kamarajan P;Fenno JC;Rickard AH;Kapila YL
代谢组学用于系统生物学，以增强对复杂疾病过程（例如癌症）的理解。头颈癌 (HNC) 是一种发生于上呼吸消化道的上皮恶性肿瘤，每年影响全球超过 50 万人。最近，重大努力集中在整合多种“组学”技术进行肿瘤研究。特别是，研究重点是使用不同的样本类型（生物体液、细胞和组织）以及各种代谢组学平台和技术来识别肿瘤特异性代谢物谱。根据我们目前对 HNC 分子异常的了解，增加代谢组学研究将增强我们对该疾病发病机制的了解，并可能有助于制定预防和治疗 HNC 的新策略。在这篇综述中，我们总结了报告 HNC 代谢组学研究结果的出版物中提出的假设和结论。此外，我们还探讨了宿主微生物代谢组学对癌症的潜在影响。从系统生物学的角度来看，基因组学、转录组学和蛋白质组学的综合应用对于未来基于转化代谢组学的研究发现极其重要。
Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significant effort has focused on integrating multiple “omics” technologies for oncological research. In particular, research has been focused on identifying tumor-specific metabolite profiles using different sample types (biological fluids, cells and tissues) and a variety of metabolomic platforms and technologies. With our current understanding of molecular abnormalities of HNC, the addition of metabolomic studies will enhance our knowledge of the pathogenesis of this disease and potentially aid in the development of novel strategies to prevent and treat HNC. In this review, we summarize the proposed hypotheses and conclusions from publications that reported findings on the metabolomics of HNC. In addition, we address the potential influence of host-microbe metabolomics in cancer. From a systems biology perspective, the integrative use of genomics, transcriptomics and proteomics will be extremely important for future translational metabolomic-based research discoveries.
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影响因子：
4.1
作者：
Beger RD
通讯作者：
Beger RD
影响因子：
3.6
作者：
Dame, Zerihun T.;Aziat, Farid;Wishart, David S.
通讯作者：
Wishart, David S.
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.
DOI：
10.1038/nrc3162
发表时间：
2011-11-17
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.1
作者：
Gowda GA;Zhang S;Gu H;Asiago V;Shanaiah N;Raftery D
通讯作者：
Raftery D