Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
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DOI：
10.1186/1471-2350-12-143
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发表时间：
2011-10-25
影响因子：
--
通讯作者：
Arakawa M
中科院分区：
文献类型：
--
作者：
Miyake Y;Tanaka K;Arakawa M
此前有六项研究检测了IL 13基因单核苷酸多态性（SNP）与变应性鼻炎之间的关系，但结果不一致。然而，最近使用这6项研究的数据进行的荟萃分析显示，IL 13 SNP rs 20541的A等位基因与变应性鼻炎的风险增加相关，而IL 13 SNP rs 1800925与变应性鼻炎之间不存在这种关系。我们调查了日本女性中IL 13 SNPs rs 1800925和rs 20541与鼻结膜炎风险之间的关联。纳入了393例符合国际儿童哮喘和过敏研究（ISAAC）鼻结膜炎标准的病例。对照组是767名根据ISAAC标准没有鼻结膜炎的妇女，她们也没有被医生诊断为过敏性鼻炎。对年龄、居住地区、是否有年长的兄弟姐妹、吸烟、过敏性鼻炎家族史和教育程度进行了调整。与IL 13 SNP rs 20541的GG基因型相比，在7.1%的对照受试者中出现的AA基因型与鼻结膜炎的风险显著正相关：调整的比值比为1.65（95%置信区间：1.05 - 2.60）。SNP rs 1800925与鼻结膜炎无关。rs 1800925 C等位基因和rs 20541 A等位基因的单倍型与鼻结膜炎显著正相关。研究中的两个SNPs和吸烟对鼻结膜炎风险的乘法交互作用没有统计学意义。然而，基于隐性模型，SNP rs 1800925与吸烟之间的加性互作显著，而rs 20541与吸烟之间的加性互作不显著。这项研究表明，IL 13 SNP rs 20541的次要基因型和CA单倍型与鼻结膜炎的风险显着正相关。此外，SNP rs 1800925和吸烟之间描述了影响鼻结膜炎风险的生物相互作用的新模式。
Six previous studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the IL13 gene and allergic rhinitis, but the results have been inconsistent. However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis. We investigated the associations between IL13 SNPs rs1800925 and rs20541 and the risk of rhinoconjunctivitis in Japanese women. Included were 393 cases who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Control subjects were 767 women without rhinoconjunctivitis according to the ISAAC criteria, who had also not been diagnosed with allergic rhinitis by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking, family history of allergic rhinitis, and education. Compared with the GG genotype of IL13 SNP rs20541, the AA genotype, occurring in 7.1% of control subjects, was significantly positively related to the risk of rhinoconjunctivitis: the adjusted odds ratio was 1.65 (95% confidence interval: 1.05 - 2.60). SNP rs1800925 was not associated with rhinoconjunctivitis. The haplotype comprising the rs1800925 C allele and the rs20541 A allele was significantly positively related to rhinoconjunctivitis. The multiplicative interactions between the two SNPs under study and smoking on the risk of rhinoconjunctivitis were not statistically significant. Based on the recessive model, however, the additive interaction between SNP rs1800925, but not rs20541, and smoking was significant. This study suggests that the minor genotype of IL13 SNP rs20541 and the CA haplotype are significantly positively associated with the risk of rhinoconjunctivitis. In addition, a new pattern of biological interaction that affects the risk of rhinoconjunctivitis is described between SNP rs1800925 and smoking.
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DOI：
10.1164/ajrccm.152.6.8520776
发表时间：
1995-12-01
影响因子：
24.7
作者：
PAWANKAR, RU;OKUDA, M;RA, CS
通讯作者：
RA, CS
影响因子：
2.8
作者：
Sakashita, Masafumi;Hirota, Tomomitsu;Fujieda, Shigeharu
通讯作者：
Fujieda, Shigeharu
影响因子：
13.6
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
通讯作者：
Ahlbom, A
影响因子：
4.4
作者：
Bunyavanich, Supinda;Shargorodsky, Josef;Celedon, Juan C.
通讯作者：
Celedon, Juan C.
影响因子：
5.8
作者：
Sadeghnejad, Alireza;Karmaus, Wilfried;Arshad, S. Hasan;Kurukulaaratchy, Ramesh;Huebner, Marianne;Ewart, Susan
通讯作者：
Ewart, Susan