Identification of group B respiratory syncytial viruses that lack the 60-nucleotide duplication after six consecutive epidemics of total BA dominance at coastal Kenya.

Identification of group B respiratory syncytial viruses that lack the 60-nucleotide duplication after six consecutive epidemics of total BA dominance at coastal Kenya.
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识别B组呼吸道合胞病毒在肯尼亚沿海沿海地区连续六次流行六次流行后,缺乏60个核苷酸重复。

DOI:
10.1111/irv.12131
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发表时间:
2013-11
影响因子:
4.4
通讯作者:
Nokes DJ
Nokes DJ
中科院分区:
医学4区
文献类型:
--
作者:
Agoti CN;Gitahi CW;Medley GF;Cane PA;Nokes DJ

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据报道,呼吸道合胞病毒BA基因型已在世界范围内取代了其他B组基因型。我们报告了2012年初在肯尼亚一家沿海地区医院观察到的三种B组病毒,它们都具有相同的G序列,但缺乏BA重复。这是在连续6次呼吸道合胞病毒(RSV)流行期间发生的,B群分离物中BA占100%优势。新毒株似乎与BA变体和2005年在该地区最后发现的先前流行的SAB1病毒只有远亲关系,这表明它们在未被发现的情况下在其他地方传播。这些结果与理解RSV持久性有关。
Respiratory syncytial virus BA genotype has reportedly replaced other group B genotypes worldwide. We report the observation of three group B viruses, all identical in G sequence but lacking the BA duplication, at a coastal district hospital in Kenya in early 2012. This follows a period of six consecutive respiratory syncytial virus (RSV) epidemics with 100% BA dominance among group B isolates. The new strains appear only distantly related to BA variants and to previously circulating SAB1 viruses last seen in the district in 2005, suggesting that they were circulating elsewhere undetected. These results are of relevance to an understanding of RSV persistence.
在肯尼亚农村的出生队列中鉴定出感染和恢复呼吸道合胞病毒菌株的遗传相关性。
DOI: 10.1093/infdis/jis570
发表时间: 2012-11-15
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影响因子: --
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