Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia.
Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia.
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婴儿和严重肺炎的幼儿对呼吸道合胞病毒的组和基因型特异性中和抗体反应。
DOI：
10.1093/infdis/jis700
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发表时间：
2013-02-01
期刊：
影响因子：
--
通讯作者：
Nokes DJ
中科院分区：
文献类型：
--
作者：
Sande CJ;Mutunga MN;Medley GF;Cane PA;Nokes DJ
遗传变异对呼吸道合胞病毒（RSV）中和抗体应答的影响知之甚少。在这项研究中，急性期和恢复期血清针对不同的RSV毒株进行了评价。在RSV A组（50% vs 12.5%; P = 0.0005）或RSV B组（40% vs 8%; P = 0.008）感染者中，同源血清转换个体的比例大于异源血清转换个体。在感染非BA病毒（35% vs 50%; P = .4）或BA病毒（50% vs 65%; P = .4）的个体中，BA基因型或非BA基因型试验病毒的血清转化率相似。RSV中和反应具有组特异性。BA相关的遗传变化没有赋予逃避先前非BA病毒的中和反应的能力。
The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non-BA genotype test viruses was similar among individuals infected with non-BA virus (35% vs 50%; P = .4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses.
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影响因子：
5.4
作者：
ANDERSON, LJ;BINGHAM, P;HIERHOLZER, JC
通讯作者：
HIERHOLZER, JC
影响因子：
5.5
作者：
Piedra, PA;Jewell, AM;Glezen, WP
通讯作者：
Glezen, WP
影响因子：
5.4
作者：
WALSH, EE;HRUSKA, J
通讯作者：
HRUSKA, J
DOI：
10.1086/606055
发表时间：
2009-11-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Nokes DJ;Ngama M;Bett A;Abwao J;Munywoki P;English M;Scott JA;Cane PA;Medley GF
通讯作者：
Medley GF
影响因子：
168.9
作者：
Nair, Harish;Nokes, D. James;Gessner, Bradford D.;Dherani, Mukesh;Madhi, Shabir A.;Singleton, Rosalyn J.;O'Brien, Katherine L.;Roca, Anna;Wright, Peter F.;Bruce, Nigel;Chandran, Aruna;Theodoratou, Evropi;Sutanto, Agustinus;Sedyaningsih, Endang R.;Ngama, Mwanajuma;Munywoki, Patrick K.;Kartasasmita, Cissy;Simoes, Eric A. F.;Rudan, Igor;Weber, Martin W.;Campbell, Harry
通讯作者：
Campbell, Harry