The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
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全身抗生素治疗复发性牙周炎患者的效果。
DOI：
10.1034/j.1600-051x.2001.028005411.x
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发表时间：
2001
影响因子：
6.7
通讯作者：
Lindhe,J
中科院分区：
文献类型：
--
作者：
Serino,G;Rosling,B;Ramberg,P;Hellström,MK;Socransky,SS;Lindhe,J
背景：患有牙周病的受试者要么（i）对初始机械治疗（“难治性”牙周炎）反应不佳，要么（ii）未能采用足够的自我执行的牙菌斑控制技术，因此在支持治疗阶段（SPT）期间在多个部位出现复发性疾病（“复发性”牙周炎）。人们已经尝试了各种全身抗生素治疗方案作为此类“难治”患者机械（再）治疗的辅助手段。虽然大多数研究表明辅助治疗取得了积极的结果，但一些临床研究人员报告说，这种额外措施几乎没有益处。目的：本研究的目的是研究辅助抗生素治疗对有明确复发性牙周炎病史的患者进行再治疗的更长期效果。材料和方法：17 名患有复发性晚期牙周病的受试者在基线检查后接受了非手术治疗，包括使用全身抗生素（阿莫西林和甲硝唑）。他们被安排在仔细的 SPT 计划中，并在 1、3 和 5 年后重新检查。检查包括临床和微生物学评估。 结果：结果表明，在患有晚期和复发性牙周炎的受试者中，再治疗包括（i）全面洁牙和根面平整（SRP），（ii）全身使用抗生素和（iii）通过机械和化学手段进行细致的龈上菌斑控制，建立了牙周状况，在短期（3年）内，大多数受试者可以通过传统的SPT措施正确维持牙周状况。然而，在 3 到 5 年之间，17 名受试者中只有 5 名表现出稳定的牙周附着水平。结论：在积极治疗阶段，一些深牙袋和分叉很可能没有得到充分的治疗。居住在这些位置的生物膜中的微生物可能没有受到两周辅助抗生素治疗的充分影响。因此，建议去除某些龈下沉积物可能需要手术干预。
Background:Subjects with periodontal disease exist who either (i) respond poorly to initial mechanical therapy (“refractory” periodontitis) or (ii) fail to adopt adequate self‐performed plaque control techniques and hence develop recurrent disease (“recurrent” periodontitis) at multiple sites during the supportive treatment phase (SPT). Various systemic antibiotic regimens have been tried as adjuncts to the mechanical (re‐) treatment of such “difficult to treat”‐patients. While most studies indicated a positive outcome of the adjunctive therapy, some clinical investigators reported that this additional measure provided little or no benefit.Aim:The aim of the present investigation was to study the more long term effect of adjunctive antibiotic therapy in the re‐treatment of patients with a well defined history of recurrent periodontitis.Material and Methods:17 subjects with recurrent advanced periodontal disease were, following a baseline examination, subjected to non‐surgical therapy including the use of systemic antibiotics (amoxicillin and metronidazole). They were placed in a careful SPT program and re‐examined after 1, 3 and 5 years. The examinations included both clinical and microbiological assessments.Results:It was demonstrated that in subjects with advanced andrecurrentperiodontitis, re‐treatment including (i) comprehensive scaling and root planing (SRP), (ii) systemic administration of antibiotics and (iii) meticulous supragingival plaque control by both mechanical and chemical means established periodontal conditions that in the short term (3 years) and in the majority of subjects could be properly maintained by traditional SPT measures. Between 3 and 5 years, however, only 5 of the 17 subjects exhibited stable periodontal attachment levels.Conclusions:Some deep pockets and furcations were most likely inadequately instrumented during the active treatment phase. Microorganisms residing in biofilms left in such locations were probably not sufficiently affected by the 2 weeks of adjunctive antibiotic therapy. It is suggested that removal of certain subgingival deposits, therefore, may require surgical intervention.
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DOI：
--
发表时间：
1969
期刊：
Odontologisk revy
影响因子：
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作者：
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DOI：
--
发表时间：
1992
期刊：
The Journal of Periodontology
影响因子：
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作者：
A. J. Winkelhoff;C. J. Tijhof;J. Graaff
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J. Graaff
影响因子：
6.7
作者：
LINDHE, J;LILJENBERG, B;BORJESSON, I
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影响因子：
6.7
作者：
S. Joyston;F. Smales;R. Duckworth
通讯作者：
R. Duckworth
三氯生对牙周炎易感受试者龈下微生物群的影响。
影响因子：
6.7
作者：
B. Rosling;G. Dahle;A. R. Volpe;Y. Furuichi;P. Ramberg;J. Lindhe
通讯作者：
J. Lindhe