Global and local morphometric differences in recently abstinent methamphetamine-dependent individuals.
Global and local morphometric differences in recently abstinent methamphetamine-dependent individuals.
复制标题
DOI：
10.1016/j.neuroimage.2010.01.056
复制
发表时间：
2010-05-01
期刊：
影响因子：
5.7
通讯作者：
Hoffman, William F.
中科院分区：
文献类型：
--
作者：
Schwartz, Daniel L.;Mitchell, Alex D.;Lahna, David L.;Luber, Hannah S.;Huckans, Marilyn S.;Mitchell, Suzanne H.;Hoffman, William F.
甲基苯丙胺（MA）与可能与宏观结构异常有关的行为和认知缺陷有关。对照组和甲基苯丙胺依赖者之间的定量解剖学比较产生了相互矛盾的结果。我们研究了61个戒断甲基苯丙胺依赖个体和44个对照组的局部和全局脑结构差异，这些个体和对照组具有基于体素的形态测量学和组织分割。我们使用多元线性回归将灰质密度和全脑分割体积的区域差异与冲动性行为测量和组成员资格的表现联系起来。在MA组中，我们将皮质和皮质下灰质密度与MA使用史、戒断时间和首次使用年龄相关。对照组在双侧额中回和左侧额中回的密度相对于MA更大。MA组的冲动性更高，在所有受试者中，冲动性与后扣带回皮质和腹侧纹状体的灰质密度呈正相关，与左额上级回呈负相关。从MA禁欲的长度与更大的杏仁核密度。首次使用MA的年龄较早（在21岁之前开始使用的受试者中）与颅内体积较小相关。这些发现与多种可能的机制一致，包括成瘾行为引起的神经适应、神经炎症以及多巴胺能和多巴胺能神经毒性。
Methamphetamine (MA) is associated with behavioral and cognitive deficits that may be related to macrostructural abnormalities. Quantitative anatomical comparisons between controls and methamphetamine-dependent individuals have produced conflicting results. We examined local and global differences in brain structure in 61 abstinent methamphetamine-dependent individuals and 44 controls with voxel-based morphometry and tissue segmentation. We related regional differences in gray matter density and whole brain segmentation volumes to performance on a behavioral measure of impulsivity and group membership using multiple linear regression. Within the MA group, we related cortical and subcortical gray matter density to MA use history, length of abstinence and age of first use. Controls had greater density relative to MA in bilateral insula and left middle frontal gyrus. Impulsivity was higher in the MA group and, within all subjects, impulsivity was positively correlated with gray matter density in posterior cingulate cortex and ventral striatum and negatively correlated in left superior frontal gyrus. Length of abstinence from MA was associated with greater amygdalar density. Earlier age of first use of MA (in subjects who initiated use before age 21) was associated with smaller intracranial volume. The findings are consistent with multiple possible mechanisms including neuroadaptations due to addictive behavior, neuroinflammation as well as dopaminergic and serotonergic neurotoxicity.
登录
查看更多内容
影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
5.7
作者：
Ballard K;Knutson B
通讯作者：
Knutson B
影响因子：
7.6
作者：
Belcher, AM;O'Dell, SJ;Marshall, JF
通讯作者：
Marshall, JF
影响因子：
56.9
作者：
Contreras, Marco;Ceric, Francisco;Torrealba, Fernando
通讯作者：
Torrealba, Fernando
影响因子：
10.6
作者：
Franklin, TR;Acton, PD;Childress, AR
通讯作者：
Childress, AR