Neural crest migration: patterns, phases and signals.
Neural crest migration: patterns, phases and signals.
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DOI：
10.1016/j.ydbio.2010.05.005
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发表时间：
2010-08-15
影响因子：
2.7
通讯作者：
Gammill, Laura S.
中科院分区：
文献类型：
--
作者：
Kulesa, Paul M.;Gammill, Laura S.
神经嵴是一种迁移的、多能的细胞类型，它形成了大量的脊椎动物结构，包括颅面骨骼和周围神经系统（Le Douarin和Kalcheim， 1999）。神经嵴细胞到达精确目标部位的能力异常导致了无数的出生缺陷。揭示产生神经嵴迁移模式的机制对于理解分子信号如何影响发育过程中结构的迁移、形态发生和分化至关重要。此外，神经嵴迁移类似于癌症转移，对高度迁移细胞类型的程序性入侵的了解可能为癌症期间的非程序性事件提供线索。神经嵴细胞从背神经管（橙色线）以弓形突的方式出现，因此神经嵴在头部的发育比在躯干的发育更早（“发育年龄”箭头）。神经嵴细胞沿典型途径（灰色）侵入周围组织，在其迁移行为中表现出三个不同的阶段（侧条）。这个理想化的胚胎以浓缩的形式说明了颅嵴和主干神经嵴迁移的模式、阶段和信号（Gammill和roffer - agarwal, 2010; Kulesa et al., 2010）。
The neural crest is a migratory, multipotent cell type that forms a vast array of vertebrate structures including the craniofacial skeleton and peripheral nervous system (Le Douarin and Kalcheim, 1999). Abnormalities in the ability of neural crest cells to reach precise target sites cause myriad birth defects. Unraveling the mechanisms that generate neural crest migratory patterns is essential to understanding how molecular signals sculpt the migration, morphogenesis, and differentiation of structures during development. Furthermore, neural crest migration resembles cancer metastasis, and insights into the programmed invasion of a highly migratory cell type may yield clues into the unprogrammed events during cancer. Neural crest cells emerge from the dorsal neural tube (orange line) in a rostrocaudal progression, so that neural crest development is more advanced in the head than in the trunk (“Developmental Age” arrow). Neural crest cells invade surrounding tissues along stereotypical pathways (grey), exhibiting three distinct phases in their migratory behaviors (side bar). This idealized embryo illustrates the patterns, phases, and signals of cranial and trunk neural crest migration in a condensed format (Gammill and Roffers-Agarwal, 2010; Kulesa et al., 2010).
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影响因子：
4.6
作者：
Roffers-Agarwal, Julaine;Gammill, Laura S.
通讯作者：
Gammill, Laura S.
影响因子：
2.5
作者：
Osborne, NJ;Begbie, J;Eickholt, BJ
通讯作者：
Eickholt, BJ
影响因子：
4.6
作者：
Kasemeier-Kulesa, Jennifer C.;Bradley, Roger;Kulesa, Paul M.
通讯作者：
Kulesa, Paul M.
影响因子：
4.6
作者：
Gammill, LS;Gonzalez, C;Bronner-Fraser, M
通讯作者：
Bronner-Fraser, M
影响因子：
4.6
作者：
Schwarz, Quenten;Vieira, Joaquim M.;Ruhrberg, Christiana
通讯作者：
Ruhrberg, Christiana