Non-invasive brain stimulation enhances the effects of melodic intonation therapy.
Non-invasive brain stimulation enhances the effects of melodic intonation therapy.
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DOI：
10.3389/fpsyg.2011.00230
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发表时间：
2011
影响因子：
3.8
通讯作者：
Schlaug G
中科院分区：
文献类型：
--
作者：
Vines BW;Norton AC;Schlaug G
研究表明，右半球的额颞叶网络可能负责调解旋律语调疗法（MIT）对语言恢复的积极影响。我们研究了一种非侵入性脑刺激技术，经颅直流电刺激（tDCS），通过在MIT治疗期间调节大脑中的神经活动来增加MIT对非流利性失语症患者的益处。施加到头皮的电流的极性决定了tDCS对底层组织的影响：阳极tDCS增加兴奋性，而阴极tDCS降低兴奋性。我们将阳极tDCS应用于右半球的额下回后部，该区域已被证明有助于通过将声音映射到发音动作来唱歌，并作为失语症恢复过程中的关键区域，特别是在左半球病变较大的患者中。刺激是由受过训练的治疗师在患者接受MIT治疗时施加的。6例中度至重度非流利性失语患者接受了连续3天的阳极tDCS + MIT，以及一系列等效的假tDCS + MIT。两个治疗系列间隔1周，治疗给药顺序随机化。与假tDCS + MIT的效果相比，阳极tDCS + MIT导致言语流畅性的显著改善。这些结果支持了这一假设，即当大脑试图重组和补偿左半球语言中心的损伤时，将阳极tDCS与MIT相结合可以通过增强右半球感觉运动网络的活动来进一步从中风后失语症中恢复。
Research has suggested that a fronto-temporal network in the right hemisphere may be responsible for mediating melodic intonation therapy’s (MIT) positive effects on speech recovery. We investigated the potential for a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), to augment the benefits of MIT in patients with non-fluent aphasia by modulating neural activity in the brain during treatment with MIT. The polarity of the current applied to the scalp determines the effects of tDCS on the underlying tissue: anodal-tDCS increases excitability, whereas cathodal tDCS decreases excitability. We applied anodal-tDCS to the posterior inferior frontal gyrus of the right hemisphere, an area that has been shown both to contribute to singing through the mapping of sounds to articulatory actions and to serve as a key region in the process of recovery from aphasia, particularly in patients with large left hemisphere lesions. The stimulation was applied while patients were treated with MIT by a trained therapist. Six patients with moderate to severe non-fluent aphasia underwent three consecutive days of anodal-tDCS + MIT, and an equivalent series of sham-tDCS + MIT. The two treatment series were separated by 1 week, and the order in which the treatments were administered was randomized. Compared to the effects of sham-tDCS + MIT, anodal-tDCS + MIT led to significant improvements in fluency of speech. These results support the hypothesis that, as the brain seeks to reorganize and compensate for damage to left hemisphere language centers, combining anodal-tDCS with MIT may further recovery from post-stroke aphasia by enhancing activity in a right hemisphere sensorimotor network for articulation.
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影响因子：
8.3
作者：
Celnik, Pablo;Paik, Nam-Jong;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
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影响因子：
8.3
作者：
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