Titania-Containing Bone Cement Shows Excellent Osteoconductivity in a Synovial Fluid Environment and Bone-Bonding Strength in Osteoporosis.
Titania-Containing Bone Cement Shows Excellent Osteoconductivity in a Synovial Fluid Environment and Bone-Bonding Strength in Osteoporosis.
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DOI：
10.3390/ma14051110
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发表时间：
2021-02-27
期刊：
影响因子：
--
通讯作者：
Matsuda S
中科院分区：
文献类型：
--
作者：
Kawata T;Goto K;Imamura M;Okuzu Y;Kawai T;Kuroda Y;Matsuda S
二氧化钛骨水泥（TBC）具有良好的体内生物活性，但其在滑液环境中的骨传导性和骨质疏松症中的骨结合能力尚未得到研究。我们旨在比较两种骨水泥在滑液环境中的骨传导性，并确定其在骨质疏松症中的骨结合能力。我们将TBC和市售聚甲基丙烯酸甲酯骨水泥（PBC）植入兔股骨髁，并将其暴露于滑液压力。然后在第6、12和26周对家兔实施安乐死，并测量亲和力指数以评价骨传导性。我们通过双侧卵巢切除术（OVX）和甲基强的松龙琥珀酸钠（PSL）治疗8周建立了一个骨质疏松症的家兔模型。假手术对照组和去卵巢+ PSL组将预硬化的TBC和PBC植入兔股骨干。在12周（40.9 ± 16.8%对24.5 ± 9.02%）和26周（40.2 ± 12.7%对21.2 ± 14.2%）时，TBC的亲和力指数显著高于PBC。在OVX + PSL组中，6周时TBC的界面剪切强度显著高于PBC（3.69 ± 1.89 N/mm 2 vs 1.71 ± 1.23 N/mm 2）。这些结果表明，TBC是一种很有前途的生物活性骨水泥，用于全膝关节置换术中的假体固定，特别是骨质疏松症患者。
Titania bone cement (TBC) reportedly has excellent in vivo bioactivity, yet its osteoconductivity in synovial fluid environments and bone-bonding ability in osteoporosis have not previously been investigated. We aimed to compare the osteoconductivity of two types of cement in a synovial fluid environment and determine their bone-bonding ability in osteoporosis. We implanted TBC and commercial polymethylmethacrylate bone cement (PBC) into rabbit femoral condyles and exposed them to synovial fluid pressure. Rabbits were then euthanized at 6, 12, and 26 weeks, and affinity indices were measured to evaluate osteoconductivity. We generated a rabbit model of osteoporosis through bilateral ovariectomy (OVX) and an 8-week treatment with methylprednisolone sodium succinate (PSL). Pre-hardened TBC and PBC were implanted into the femoral diaphysis of the rabbits in the sham control and OVX + PSL groups. Affinity indices were significantly higher for TBC than for PBC at 12 weeks (40.9 ± 16.8% versus 24.5 ± 9.02%) and 26 weeks (40.2 ± 12.7% versus 21.2 ± 14.2%). The interfacial shear strength was significantly higher for TBC than for PBC at 6 weeks (3.69 ± 1.89 N/mm2 versus 1.71 ± 1.23 N/mm2) in the OVX + PSL group. These results indicate that TBC is a promising bioactive bone cement for prosthesis fixation in total knee arthroplasty, especially for osteoporosis patients.
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DOI：
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发表时间：
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影响因子：
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影响因子：
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DOI：
10.4081/ejh.2014.2255
发表时间：
2014-06-23
期刊：
European journal of histochemistry : EJH
影响因子：
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作者：
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