The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth.
The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth.
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DOI：
10.1371/journal.pone.0006648
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发表时间：
2009-09-24
期刊：
影响因子：
3.7
通讯作者：
Perrot-Rechenmann C
中科院分区：
文献类型：
--
作者：
Tromas A;Braun N;Muller P;Khodus T;Paponov IA;Palme K;Ljung K;Lee JY;Benfey P;Murray JA;Scheres B;Perrot-Rechenmann C
在植物中，植物激素生长素是维持生长和发育的重要调节剂。在细胞水平上，生长素以组织和剂量依赖的方式被差异地解释。生长素信号传导的机制部分未知，生长素结合蛋白1（ABP 1）作为生长素受体的作用仍然是一个有争议的问题。在这里，我们利用目前的知识，根生物系统，以证明ABP 1所需的生长素反应。条件ABP 1缺陷植物的使用揭示了该蛋白质对于根分生组织的维持是必需的，并且至少作用于D型细胞周期蛋白/视网膜母细胞瘤途径以控制进入细胞周期。ABP 1影响PLETHORA梯度并赋予根细胞生长素敏感性，从而限定细胞在分生组织内维持或伸长的能力。ABP 1还参与响应于生长素的基因表达的调节。我们的数据支持ABP 1是根生长的关键调节因子，并且是生长素介导的反应所必需的。ABP 1对各种生长素反应的差异效应支持了一个模型，其中ABP 1是生长素对细胞周期的作用的主要调节剂，并且除了已经熟知的TIR 1介导的泛素化途径之外，还调节生长素介导的基因表达和细胞伸长。
In plants, the phytohormone auxin is a crucial regulator sustaining growth and development. At the cellular level, auxin is interpreted differentially in a tissue- and dose-dependent manner. Mechanisms of auxin signalling are partially unknown and the contribution of the AUXIN BINDING PROTEIN 1 (ABP1) as an auxin receptor is still a matter of debate. Here we took advantage of the present knowledge of the root biological system to demonstrate that ABP1 is required for auxin response. The use of conditional ABP1 defective plants reveals that the protein is essential for maintenance of the root meristem and acts at least on the D-type CYCLIN/RETINOBLASTOMA pathway to control entry into the cell cycle. ABP1 affects PLETHORA gradients and confers auxin sensitivity to root cells thus defining the competence of the cells to be maintained within the meristem or to elongate. ABP1 is also implicated in the regulation of gene expression in response to auxin. Our data support that ABP1 is a key regulator for root growth and is required for auxin-mediated responses. Differential effects of ABP1 on various auxin responses support a model in which ABP1 is the major regulator for auxin action on the cell cycle and regulates auxin-mediated gene expression and cell elongation in addition to the already well known TIR1-mediated ubiquitination pathway.
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影响因子：
64.8
作者：
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