Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo.
Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo.
复制标题
DOI：
10.1002/dvdy.21899
复制
发表时间：
2009-04
影响因子：
2.5
通讯作者：
Myat, Monn Monn
中科院分区：
文献类型：
--
作者：
Jattani, Rakhi;Patel, Unisha;Kerman, Bilal;Myat, Monn Monn
The Drosophila embryonic salivary gland is an epithelial organ formed by the coordinated invagination and migration of primordial cells. To identify genes that regulate gland migration we performed a deficiency screen of the third chromosome. Here, we report on the analysis of the beta 2 tubulin isoform (β2t) that maps at 85D15. We show that in β2t mutant embryos, salivary glands did not complete their posterior migration and that migration of fusion competent myoblasts (FCMs) and longitudinal visceral muscle founder (LVMF) cells between the gland and CVM was delayed. We also demonstrate that gland migration defects correlate with reduced βPS and αPS2 integrin expression in the surrounding mesoderm and that β2t genetically interacts with genes encoding integrin αPS1 and αPS2 subunits. Our studies reveal for the first time that β2t is expressed in embryogenesis and that β2t plays an important role in salivary gland and myoblast migration, possibly through proper regulation of integrin adhesion proteins.
登录
查看更多内容
影响因子：
64.5
作者：
Mukouyama, Y;Shin, D;Anderson, DJ
通讯作者：
Anderson, DJ
影响因子：
64.5
作者：
KEMPHUES, KJ;KAUFMAN, TC;RAFF, EC
通讯作者：
RAFF, EC
影响因子：
7.8
作者：
FULLER, MT;CAULTON, JH;RAFF, EC
通讯作者：
RAFF, EC
影响因子：
64.5
作者：
Keays DA;Tian G;Poirier K;Huang GJ;Siebold C;Cleak J;Oliver PL;Fray M;Harvey RJ;Molnár Z;Piñon MC;Dear N;Valdar W;Brown SD;Davies KE;Rawlins JN;Cowan NJ;Nolan P;Chelly J;Flint J
通讯作者：
Flint J
影响因子：
11.4
作者：
BIALOJAN, S;FALKENBURG, D;RENKAWITZPOHL, R
通讯作者：
RENKAWITZPOHL, R