Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans
Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans
复制标题
人类威胁逆转后双侧海马的多巴胺能可塑性
DOI：
10.1038/s41598-020-63977-7
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发表时间：
2020
影响因子：
4.6
通讯作者：
C. Benkelfat
中科院分区：
文献类型：
--
作者：
Jennifer I Lissemore;A. Nagano;Kelly Smart;P. Gravel;M. Leyton;C. Benkelfat
当线索不再预示威胁时，消除或逆转这种联系的能力减弱被认为会增加患压力相关疾病的风险。尽管有明确的临床相关性，但对威胁逆转的神经化学机制的研究相对较少。在啮齿动物研究中涉及到的一种神经递质是多巴胺。为了研究多巴胺是否参与人类的威胁逆转，我们使用了高分辨率正电子发射断层扫描（PET）和18F-fallypride。12名健康志愿者（6名F/6名M）接受了三次PET扫描：(i)基线时，（ii）威胁条件反射后（对与手腕电击相关的提示的反应），（iii）威胁逆转后（对现在与安全相关的同一提示的反应）。我们观察到适度的证据表明，在威胁逆转后，在对先前与威胁相关的安全提示作出反应时，在双侧前海马体中，与基线和威胁逆转前暴露于相同提示时相比，多巴胺D2/3受体可用性降低，与多巴胺释放增加一致。这些发现提供了第一个初步证据，证明健康人对先前威胁提示的反应与安全有关，涉及海马体内多巴胺能神经传递。
When a cue no longer predicts a threat, a diminished ability to extinguish or reverse this association is thought to increase risk for stress-related disorders. Despite the clear clinical relevance, the mediating neurochemical mechanisms of threat reversal have received relatively little study. One neurotransmitter implicated in rodent research of changing associations with threat is dopamine. To study whether dopamine is involved in threat reversal in humans, we used high-resolution positron emission tomography (PET) coupled with 18F-fallypride. Twelve healthy volunteers (6 F/6 M) underwent three PET scans: (i) at baseline, (ii) following threat conditioning (the response to a cue associated with electric wrist shock), and (iii) following threat reversal (the response to the same cue now associated with safety). We observed moderate evidence of reduced dopamine D2/3 receptor availability, consistent with greater dopamine release, in the bilateral anterior hippocampus following threat reversal, in response to a safety cue that was previously associated with threat, as compared to both baseline and during exposure to the same cue prior to threat reversal. These findings offer the first preliminary evidence that the response to a previously threatening cue that has since become associated with safety involves dopaminergic neurotransmission within the hippocampus in healthy humans.
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影响因子：
3.7
作者：
Pineles SL;Orr MR;Orr SP
通讯作者：
Orr SP
影响因子：
1.9
作者：
BRADLEY, MM;LANG, PJ;CUTHBERT, BN
通讯作者：
CUTHBERT, BN
恐惧灭绝作为转化神经科学的模型：十年的进步。
影响因子：
24.8
作者：
Milad MR;Quirk GJ
通讯作者：
Quirk GJ
影响因子：
4.8
作者：
Milad, Mohammed R.;Orr, Scott P.;Pitman, Roger K.
通讯作者：
Pitman, Roger K.
DOI：
10.1073/pnas.1303061110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Haaker, Jan;Gaburro, Stefano;Kalisch, Raffael
通讯作者：
Kalisch, Raffael