Parietal gray matter volume loss is related to spatial processing deficits in long-term abstinent alcoholic men.
Parietal gray matter volume loss is related to spatial processing deficits in long-term abstinent alcoholic men.
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DOI：
10.1111/j.1530-0277.2009.01019.x
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Barakos J
中科院分区：
文献类型：
--
作者：
Fein G;Shimotsu R;Chu R;Barakos J
与年龄和性别相似的非酒精对照组(NAC)相比，我们先前在中年长期戒酒(LTAA，戒酒6个月或更长时间)中显示出相对完整的认知功能(除了空间信息处理持续缺陷的提示证据)。在目前的研究中，我们检查了相同样本中的皮质灰质体积，以确定LTAA中的灰质体积是否与认知结果一致-即，在大多数大脑区域显示的灰质体积与NAC相当，除了可能存在的顶叶持续萎缩的迹象，以辅助空间信息处理。我们发现顶叶LTAA的灰质萎缩与同一样本的空间加工缺陷一致。更引人注目的是，在LTAA中，顶叶灰质萎缩的程度与空间加工领域的表现呈负相关，与酒精剂量呈正相关。在枕叶视觉关联区和其他较小的区域也观察到灰质体积显著减少，但没有发现与饮酒有关，这表明在其他区域，顶叶体积缺陷比灰质丢失更持久。总而言之，认知和结构成像数据提供了令人信服的证据，表明长期酗酒会导致顶叶皮质萎缩，并伴随着空间信息处理方面的缺陷。
We previously demonstrated relatively intact cognitive function (with the exception of suggestive evidence for persistent deficits in spatial information processing) in middle-aged long-term abstinent alcoholics (LTAA, abstinent for 6 months or more) compared to age and gender comparable non-alcoholic controls (NAC). In the current study, we examine cortical gray matter volumes in the same samples to determine whether gray matter volumes in LTAA are consistent with the cognitive results – i.e., exhibiting gray matter volumes comparable to NAC in most brain regions, except for possible indications of persistent shrinkage in the parietal lobe subserving spatial information processing. We found gray matter shrinkage in LTAA in the parietal lobe consistent with the spatial processing deficits in this same sample. More compelling, in LTAA, the magnitude of parietal gray matter shrinkage was negatively associated with spatial processing domain performance and positively associated with alcohol dose. Significantly reduced gray matter volumes were also observed within the visual association region of the occipital lobe as well as in other smaller regions, but no associations with alcohol intake were found, suggesting that parietal lobe volume deficits were more persistent than gray matter loss in other regions. Taken together, the cognitive and structural imaging data provide compelling evidence that chronic alcohol abuse results in shrinkage of the parietal cortex with associated deficits in spatial information processing.
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