Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations.
Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations.
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DOI：
10.1586/ern.12.49
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发表时间：
2012-06
影响因子：
4.3
通讯作者：
Louis ED
中科院分区：
文献类型：
--
作者：
Thenganatt MA;Louis ED
区分帕金森氏病和特发性震颤可能具有挑战性，无论是在这些疾病的早期阶段，还是随着这些疾病的进展。各种震颤类型(静息、姿势、运动和意图)可见于特发性震颤和帕金森氏病。此外，随着时间的推移，这两种疾病可能会在一个患者体内共存。详细的临床检查，注意震颤的具体特征(频率、幅度、模式和分布)以及相关的神经学表现，可能有助于区分这两种疾病的患者。实验室检测可能提供进一步帮助区分这两种疾病的信息。这些测试包括加速计量术和表面肌电图、螺旋分析、多巴胺转运体成像、嗅觉测试以及最终的尸检组织病理学。这些测试都有局限性，它们的诊断效用需要进一步研究。
Distinguishing essential tremor from Parkinson’s disease can be challenging, both in the early stages of these diseases and as these diseases progress. Various tremor types (rest, postural, kinetic and intention) may be seen in both essential tremor and Parkinson’s disease. Furthermore, with time, the two diseases may coexist within a single patient. Detailed clinical examination with attention to specific features of tremor (frequency, amplitude, pattern and distribution) and associated neurological findings may help distinguish patients with the two diseases. Laboratory testing may provide information that further aids in differentiating the two diseases. These tests include accelerometry and surface electromyography, spiral analysis, dopamine transporter imaging, olfactory testing and, eventually, postmortem histopathology. These tests have limitations and their diagnostic utility requires additional study.
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