Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review.
Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review.
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DOI：
10.3390/ph14020075
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发表时间：
2021-01-20
期刊：
影响因子：
--
通讯作者：
Nune M
中科院分区：
文献类型：
--
作者：
Al-Harbi N;Mohammed H;Al-Hadeethi Y;Bakry AS;Umar A;Hussein MA;Abbassy MA;Vaidya KG;Berakdar GA;Mkawi EM;Nune M
再生医学是一个领域，旨在影响和即兴组织修复和恢复的过程，并协助身体愈合和恢复。在硬组织再生领域，主要使用生物惰性材料，并且有必要使用生物活性材料，其可以帮助更好的组织-植入物相互作用并促进愈合和再生过程。在过去的几十年里，一种这样的生物活性材料被广泛关注和研究，这就是生物活性玻璃（BG）。最初的生物活性玻璃（45 S5）由二氧化硅、二氧化钠、氧化钙和五氧化二磷组成，主要以其商业名称Bioglass来指代。由于其骨传导性和骨刺激特性，BG主要用于骨组织再生。然而，BG的生物活性高度依赖于某些玻璃形成系统含量的组成比。BG形成网络的含量比和元素组成灵活性的操纵开发了其他类型的生物活性玻璃，其具有可控的化学耐久性和与骨的化学亲和力以及生物活性。本文主要讨论了硅基生物活性玻璃的基本信息，包括它们的组成、加工和性能，以及它们在骨再生、骨移植和牙科植入物涂层等方面的医学应用。
Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue–implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dioxide, sodium dioxide, calcium oxide, and phosphorus pentoxide and is mainly referred to by its commercial name Bioglass. BG is mainly used for bone tissue regeneration due to its osteoconductivity and osteostimulation properties. The bioactivity of BG, however, is highly dependent on the compositional ratio of certain glass-forming system content. The manipulation of content ratio and the element compositional flexibility of BG-forming network developed other types of bioactive glasses with controllable chemical durability and chemical affinity with bone and bioactivity. This review article mainly discusses the basic information about silica-based bioactive glasses, including their composition, processing, and properties, as well as their medical applications such as in bone regeneration, as bone grafts, and as dental implant coatings.
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