Designing Phase II B trials in sarcopenia: the best target population.
Designing Phase II B trials in sarcopenia: the best target population.
复制标题
在肌肉减少症中设计II期B试验：最佳目标人群。
DOI：
10.1007/s12603-011-0058-9
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发表时间：
2011-08
影响因子：
5.8
通讯作者：
Cesari, M.
中科院分区：
文献类型：
--
作者：
Pahor, M.;Cesari, M.
Despite the existing limitations and controversies regarding the definition of sarcopenia and its clinical consequences, the current scientific evidence strongly suggests that muscle decline is a primary determinant of the disabling process (and likely of other major health-related events). In fact, the muscle loss (in terms of mass as well as strength) occurring with aging has been growingly associated with mobility impairment and disability in older persons. Unfortunately, current evidence is mainly from observational studies. Times are mature to begin testing interventions aimed at modifying the sarcopenia process through the design and development of specific clinical trials. Considering the emergence of many promising interventions towards this age-related condition (e.g., physical exercise [in particular, resistance training], testosterone, antioxidant supplementations), the need for Phase II trial designs is high. In the present report, we discuss which are the major issues related to the design of Phase II clinical trials on sarcopenia with particular focus on the participant's characteristics to be considered as possible inclusion and exclusion criteria.
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影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1093/gerona/63.8.829
发表时间：
2008-08-01
影响因子：
5.1
作者：
Clark, Brian C.;Manini, Todd M.
通讯作者：
Manini, Todd M.
DOI：
10.1002/art.23719
发表时间：
2008-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Giles, Jon T.;Ling, Shari M.;Bathon, Joan M.
通讯作者：
Bathon, Joan M.
DOI：
10.1152/ajpendo.00394.2006
发表时间：
2007-07-01
影响因子：
5.1
作者：
Azuma, Koichiro;Heilbronn, Leonie K.;Kelley, David E.
通讯作者：
Kelley, David E.
DOI：
10.1093/gerona/57.5.m283
发表时间：
2002-05-01
影响因子：
5.1
作者：
Bortz, WM
通讯作者：
Bortz, WM