Vitamin A Nutritional Status Is a Key Determinant of Bone Mass in Children.
Vitamin A Nutritional Status Is a Key Determinant of Bone Mass in Children.
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DOI：
10.3390/nu14214694
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发表时间：
2022-11-06
期刊：
影响因子：
5.9
通讯作者：
Zhang, Zheqing
中科院分区：
文献类型：
--
作者：
Zhang, Xuanrui;Huang, Jiapeng;Zhou, Yingyu;Hong, Zhen;Lin, Xiaoping;Chen, Shanshan;Ye, Yongnong;Zhang, Zheqing
儿童时期的骨量增加对于最大化成人的峰值骨量和预防骨质疏松症具有重要意义。研究表明，VA可以改善成年人的骨骼健康。此外，有限的研究评估了儿童中的这种联系。在这项横断面研究中，包括426名儿童，我们评估了儿童的血浆视黄醇浓度的液相色谱-质谱法和饮食摄入的VA和类胡萝卜素使用结构化的食物频率问卷。采用双能X线骨密度仪测定骨矿含量和骨密度。校正潜在混杂因素后，限制性三次样条曲线显示血浆视黄醇浓度与BMD之间呈倒U型相关;血浆视黄醇浓度每增加1 μmol/L对TBLH BMD的估计影响为低于1.24 μmol/L时为1.79 × 10−2 g/cm 2，高于1.24 μmol/L时为−5.78 × 10−3 g/cm 2（非线性p = 0.046）。多元线性回归分析显示，血浆视黄醇浓度与TBLH BMC呈正相关（β = 1.89，95% CI：1.64 × 10−1-3.62，p = 0.032）。总之，适当的血浆视黄醇浓度和更大的膳食VA和β-胡萝卜素的摄入量可以提高6-9岁儿童的骨矿物质状态。
The bone mass increases that occur during the period of childhood are of great significance for maximizing the peak bone mass in adults and preventing for osteoporosis. Studies have reported that VA can improve the bone health in adults. Moreover, limited studies have assessed such associations in children. In this cross-sectional study including 426 children, we assessed the children’s plasma retinol concentration by liquid chromatography–mass spectrometry and the dietary intake of VA and carotenoids using a structured Food Frequency Questionnaire. Their bone mineral content and bone mineral density (BMD) were measured using dual-energy X-ray absorptiometry. After adjusting for potential confounders, the restricted cubic spline revealed an inverted U-shaped association between plasma retinol concentration and BMD; the estimated effects on the TBLH BMD per μmol/L increase in the plasma retinol concentration were 1.79 × 10−2 g/cm2 below 1.24 μmol/L and −5.78 × 10−3 g/cm2 above this point (p for non-linearity = 0.046). A multiple linear regression analysis revealed a positive association between the plasma retinol concentration and the TBLH BMC (β = 1.89, 95% CI: 1.64 × 10−1–3.62, p = 0.032). In conclusion, an appropriate plasma retinol concentration and greater intakes of dietary VA and β-carotene may enhance the bone mineral status of children who are aged 6–9 years.
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美国成年人不同种族种族中血清维生素与骨矿物质密度的关联。
影响因子：
2.3
作者：
Li X;Liu X
通讯作者：
Liu X
影响因子：
158.5
作者：
Michaëlsson, K;Lithell, H;Melhus, H
通讯作者：
Melhus, H
影响因子：
4.1
作者：
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通讯作者：
Cherubini, A
影响因子：
5.9
作者：
Regu GM;Kim H;Kim YJ;Paek JE;Lee G;Chang N;Kwon O
通讯作者：
Kwon O
DOI：
10.1016/j.beem.2011.05.002
发表时间：
2011-08-01
影响因子：
7.4
作者：
Lips, Paul;van Schoor, Natasja M.
通讯作者：
van Schoor, Natasja M.