Intact memory for irrelevant information impairs perception in amnesia.
Intact memory for irrelevant information impairs perception in amnesia.
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DOI：
10.1016/j.neuron.2012.05.014
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发表时间：
2012-07-12
期刊：
影响因子：
16.2
通讯作者：
Henson RN
中科院分区：
文献类型：
--
作者：
Barense MD;Groen II;Lee AC;Yeung LK;Brady SM;Gregori M;Kapur N;Bussey TJ;Saksida LM;Henson RN
记忆和感知一直被认为是独立的认知过程，由内侧颞叶（MTL）损伤引起的健忘症被认为反映了专用记忆系统的损伤。最近的研究对这些观点提出了质疑，认为失忆症可能是由于MTL中知觉表征的贫乏，导致对干扰的易感性增加。利用fMRI涉及特定MTL结构的感知匹配任务，我们发现MTL损伤的失忆症包括鼻周皮层，但不包括仅限于海马的损伤，容易受到基于物体的感知干扰。重要的是，当我们控制这种干扰时，它们的性能恢复到正常水平。这些发现挑战了流行的失忆症概念，表明对特定MTL区域的损害不是从专门的陈述性记忆系统的损害方面更好地理解，而是从这些区域维持的刺激的贫困表征方面理解。►减少对物体的知觉干扰可以挽救PRC损伤的失忆症患者的表现►PRC损伤后的记忆丧失可以反映对干扰的敏感性增加►客体表征的匮乏可能导致失忆症Barense和同事证明，内侧颞叶损伤的失忆症患者的知觉缺陷可以通过减少视觉相似的干扰来挽救刺激。这些发现挑战了目前关于健忘症和记忆的神经基础的观点。
Memory and perception have long been considered separate cognitive processes, and amnesia resulting from medial temporal lobe (MTL) damage is thought to reflect damage to a dedicated memory system. Recent work has questioned these views, suggesting that amnesia can result from impoverished perceptual representations in the MTL, causing an increased susceptibility to interference. Using a perceptual matching task for which fMRI implicated a specific MTL structure, the perirhinal cortex, we show that amnesics with MTL damage including the perirhinal cortex, but not those with damage limited to the hippocampus, were vulnerable to object-based perceptual interference. Importantly, when we controlled such interference, their performance recovered to normal levels. These findings challenge prevailing conceptions of amnesia, suggesting that effects of damage to specific MTL regions are better understood not in terms of damage to a dedicated declarative memory system, but in terms of impoverished representations of the stimuli those regions maintain. ► Perception can be impaired in amnesia resulting from perirhinal cortex (PRC) damage ► Reducing object perceptual interference can rescue PRC-damaged amnesics' performance ► Memory loss after PRC damage can reflect heightened susceptibility to interference ► Impoverished object representations may contribute to amnesia Barense and colleagues demonstrate that perceptual deficits in amnesic patients with medial temporal lobe damage can be rescued by reducing interference from visually similar stimuli. These findings challenge current views on amnesia and the neural basis of memory.
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影响因子：
3.5
作者：
Barense, Morgan D.;Henson, Richard N. A.;Lee, Andy C. H.;Graham, Kim S.
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作者：
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作者：
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