Correction method for influence of tissue scattering for sidestream dark-field oximetry using multicolor LEDs
Correction method for influence of tissue scattering for sidestream dark-field oximetry using multicolor LEDs
复制标题
使用多色 LED 进行侧流暗场血氧测定时组织散射影响的校正方法
DOI：
10.1007/s10043-016-0278-7
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发表时间：
2016
期刊：
影响因子：
1.2
通讯作者：
Hideaki Haneishi
中科院分区：
文献类型：
--
作者：
Tomohiro Kurata;Shigeto Oda;Hiroshi Kawahira;Hideaki Haneishi
我们之前提出了一种从侧流暗场（SDF）成像（我们称之为SDF血氧饱和度法）获得的图像中估计血管内氧饱和度的方法，并通过蒙特卡罗模拟研究了其基本特征。本文提出了一种校正组织散射的方法，并通过浊影实验和蒙特卡罗模拟实验研究了组织散射对SDF成像的影响。在估计方法中，我们使用血红蛋白的修正消光系数称为平均消光系数（AECs）来校正来自光源带宽、成像相机特性和组织散射的影响。我们从SDF图像中沿垂直于血管运行方向的直线的像素值剖面的最大斜率估计组织的散射系数，并利用散射系数校正aec。为了评估所提出的方法，我们开发了一种实验性的SDF探针，通过开关多色发光二极管获得三波段图像，并获得了由琼脂粉、脂肪乳和牛血填充玻璃管组成的浑浊幻影图像。结果发现，幻体散射的增加会导致aec的降低。实验结果表明，采用合适的aec值可以得到更准确的估计。我们还验证了所提出的修正方法的有效性，以提高估计的准确性。
We have previously proposed an estimation method of intravascular oxygen saturationfrom the images obtained by sidestream dark-field (SDF) imaging (we call it SDF oximetry) and we investigated its fundamental characteristics by Monte Carlo simulation. In this paper, we propose a correction method for scattering by the tissue and performed experiments with turbid phantoms as well as Monte Carlo simulation experiments to investigate the influence of the tissue scattering in the SDF imaging. In the estimation method, we used modified extinction coefficients of hemoglobin called average extinction coefficients (AECs) to correct the influence from the bandwidth of the illumination sources, the imaging camera characteristics, and the tissue scattering. We estimate the scattering coefficient of the tissue from the maximum slope of pixel value profile along a line perpendicular to the blood vessel running direction in an SDF image and correct AECs using the scattering coefficient. To evaluate the proposed method, we developed a trial SDF probe to obtain three-band images by switching multicolor light-emitting diodes and obtained the image of turbid phantoms comprised of agar powder, fat emulsion, and bovine blood-filled glass tubes. As a result, we found that the increase of scattering by the phantom body brought about the decrease of the AECs. The experimental results showed that the use of suitable values for AECs led to more accurateestimation. We also confirmed the validity of the proposed correction method to improve the accuracy of theestimation.
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影响因子：
46.9
作者：
Zhang, Hao F.;Maslov, Konstantin;Wang, Lihong V.
通讯作者：
Wang, Lihong V.
多光路对视网膜血管血氧饱和度的影响。
影响因子：
1.9
作者：
Matthew H. Smith;K. Denninghoff;A. Lompado;L. W. Hillman
通讯作者：
L. W. Hillman
影响因子：
--
作者：
PRIES, AR;KANZOW, G;GAEHTGENS, P
通讯作者：
GAEHTGENS, P
影响因子：
3.5
作者：
Yao, Junjie;Maslov, Konstantin I.;Wang, Lihong V.
通讯作者：
Wang, Lihong V.