The anatomical and functional relationship between the P3 and autonomic components of the orienting response.
The anatomical and functional relationship between the P3 and autonomic components of the orienting response.
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DOI：
10.1111/j.1469-8986.2010.01057.x
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发表时间：
2011-02
期刊：
影响因子：
3.7
通讯作者：
Aston-Jones G
中科院分区：
文献类型：
--
作者：
Nieuwenhuis S;De Geus EJ;Aston-Jones G
许多心理生理学家已经注意到，事件相关电位的P3成分和定向反应的前因条件之间有着惊人的相似之处：两者通常都是由显著的、意外的、新颖的、任务相关的和其他动机显著的刺激引起的。虽然P3和定向反应的紧密耦合已经有了很好的记录，但这种关系的神经基础和功能作用仍然知之甚少。在这里，我们提出，同时发生的P3和自主成分的定向反应反映了蓝斑去甲肾上腺素系统和外周交感神经系统的共同激活的共同主要传入：延髓头端腹外侧，一个关键的交感兴奋区。蓝斑-去甲肾上腺素系统和外周交感神经系统的功能意义的比较表明，P3和定向反应反映了互补的认知和身体的贡献动员行动后，动机显着的刺激。
Many psychophysiologists have noted the striking similarities between the antecedent conditions for the P3 component of the event-related potential and the orienting response: both are typically elicited by salient, unexpected, novel, task-relevant, and other motivationally significant stimuli. Although the close coupling of the P3 and orienting response has been well documented, the neural basis and functional role of this relationship is still poorly understood. Here we propose that the simultaneous occurrence of the P3 and autonomic components of the orienting response reflects the co-activation of the locus coeruleus-norepinephrine system and the peripheral sympathetic nervous system by their common major afferent: the rostral ventrolateral medulla, a key sympathoexcitatory region. A comparison of the functional significance of the locus coeruleus-norepinephrine system and the peripheral sympathetic nervous system suggests that the P3 and orienting response reflect complementary cognitive and physical contributions to the mobilization for action following motivationally significant stimuli.
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