Measles elimination efforts and 2008-2011 outbreak, France.
Measles elimination efforts and 2008-2011 outbreak, France.
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DOI：
10.3201/eid1903.121360
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发表时间：
2013-03
影响因子：
11.8
通讯作者：
Parent du Chatelet I
中科院分区：
文献类型：
--
作者：
Antona D;Lévy-Bruhl D;Baudon C;Freymuth F;Lamy M;Maine C;Floret D;Parent du Chatelet I
尽管 2006 年和 2007 年期间法国报告的麻疹病例很少，这表明该国可能已接近消除这种疾病，但 2008 年至 2011 年期间却发生了超过 20,000 例麻疹病例的急剧爆发。青少年和青壮年占病例的一半以上；疫情期间患者中位年龄从 12 岁增加到 16 岁。 1岁以下儿童发病率最高，上一波疫情期间达到135例/10万婴儿。近5,000名患者住院治疗，其中1,023人因重症肺炎住院，27人因脑炎/脊髓炎住院； 10名患者死亡。在此期间，超过 80% 的病例发生在未接种疫苗的人群中，反映出疫苗接种覆盖率参差不齐，仍然存在少数易感人群。尽管儿童疫苗覆盖率有所提高，但如果要实现到 2015 年消除该疾病的目标，说服易感年轻人接种疫苗仍然是一个关键问题。
Although few measles cases were reported in France during 2006 and 2007, suggesting the country might have been close to eliminating the disease, a dramatic outbreak of >20,000 cases occurred during 2008–2011. Adolescents and young adults accounted for more than half of cases; median patient age increased from 12 to 16 years during the outbreak. The highest incidence rate was observed in children <1 year of age, reaching 135 cases/100,000 infants during the last epidemic wave. Almost 5,000 patients were hospitalized, including 1,023 for severe pneumonia and 27 for encephalitis/myelitis; 10 patients died. More than 80% of the cases during this period occurred in unvaccinated persons, reflecting heterogeneous vaccination coverage, where pockets of susceptible persons still remain. Although vaccine coverage among children improved, convincing susceptible young adults to get vaccinated remains a critical issue if the target to eliminate the disease by 2015 is to be met.
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