The relationship between processing speed and working memory demand in systemic lupus erythematosus: evidence from a visual n-back task.
The relationship between processing speed and working memory demand in systemic lupus erythematosus: evidence from a visual n-back task.
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DOI：
10.1037/a0021218
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发表时间：
2011-01
期刊：
影响因子：
2.4
通讯作者：
Shucard DW
中科院分区：
文献类型：
--
作者：
Shucard JL;Lee WH;Safford AS;Shucard DW
系统性红斑狼疮（SLE）患者的工作记忆（WM）缺陷已有报道，但SLE患者的信息处理速度（PS）与WM缺陷之间的关系尚不清楚。本研究探讨了PS减慢是否可以解释在SLE中观察到的WM缺陷。采用视觉n-back任务测量40例SLE患者和36例健康对照者的简单和复杂PS和WM。简单PS被定义为在非常低的WM负荷条件（0-back）下校正反应的反应时（RT），而复杂PS被定义为在中等和高WM负荷条件（1和2-back）下校正反应的RT。结果表明，SLE患者在较低的工作记忆负荷条件下的正确反应与对照组相当，但在最高工作记忆负荷条件下（2-back）的正确反应低于对照组。在所有条件下，SLE患者的RT比对照组慢，但在较高WM负荷条件下，他们的RT比对照组慢。此外，当从复杂PS中减去简单PS的RT时，与对照组相比，SLE患者仍然显示出1-back和2-back的复杂PS较慢。简单和复杂PS减慢与2-back条件下的准确性评分较差相关，仅适用于SLE组。n-back任务提供了PS和WM的敏感测量。结果表明，PS缺陷单独不能解释WM缺陷在SLE。疾病的持续时间，疾病活动，抑郁症似乎并没有解释所观察到的PS和WM赤字。
Working memory (WM) deficits have been reported previously in systemic lupus erythematosus (SLE), but the relationship between information processing speed (PS) and WM deficits in SLE is unknown. This study examined whether or not PS slowing could account for the WM deficits observed in SLE. A visual n-back task was used to measure simple and complex PS and WM in 40 SLE patients and 36 healthy controls. Simple PS was defined as reaction time (RT) to correct responses under a very low WM load condition (0-back), while complex PS was defined as RT to correct responses under moderate and high WM load conditions (1 and 2-back). The results showed that SLE patients performed as well as the controls at the lower WM load conditions but had fewer correct responses than controls under the highest WM load condition (2-back). SLE patients had slower RTs than controls under all conditions, but they had relatively greater RT slowing than controls under the higher WM load conditions. Further, when RT for simple PS was subtracted from complex PS, SLE patients still showed slower complex PS for the 1 and 2-back compared to controls. Both simple and complex PS slowing were related to poorer accuracy scores on the 2-back condition, only for the SLE group. The n-back task provides a sensitive measure of PS and WM. The results suggest that PS deficits alone could not account for the WM deficits in SLE. Disease duration, disease activity, and depression did not appear to account for the observed PS and WM deficits.
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DOI：
10.1017/s1355617701766106
发表时间：
2001-09-01
影响因子：
2.6
作者：
Kozora, E;Laudenslager, M;West, SG
通讯作者：
West, SG
影响因子：
--
作者：
Kozora, E;Thompson, LL;Kotzin, BL
通讯作者：
Kotzin, BL
DOI：
10.1017/s1355617707070580
发表时间：
2007-05-01
影响因子：
2.6
作者：
Parmenter, Brett A.;Shucard, Janet L.;Shucard, David W.
通讯作者：
Shucard, David W.
影响因子：
3.7
作者：
Carlson, S;Martinkauppi, S;Aronen, HJ
通讯作者：
Aronen, HJ
影响因子：
6.9
作者：
Nebes, RD;Butters, MA;Reynolds, CF
通讯作者：
Reynolds, CF