Basal ganglia circuit loops, dopamine and motivation: A review and enquiry.
Basal ganglia circuit loops, dopamine and motivation: A review and enquiry.
复制标题
DOI：
10.1016/j.bbr.2015.04.018
复制
发表时间：
2015-09-01
影响因子：
2.7
通讯作者：
Tan, Aaron
中科院分区：
文献类型：
--
作者：
Ikemoto, Satoshi;Yang, Chen;Tan, Aaron
位于中脑的多巴胺神经元在调节接近行为（接近动机）的动机中发挥作用。此外，多巴胺神经元的激活和失活分别调节情绪并诱导奖赏和厌恶。越来越多的证据表明，这种多巴胺神经元的动机作用不仅限于腹侧被盖区，而且在黑质。本文回顾了以往的啮齿类动物的工作，多巴胺的接近动机和多巴胺神经元的连接的作用，并提出了两个工作模型：一个关注细胞外多巴胺浓度和接近动机之间的关系。高、中、低浓度的细胞外多巴胺分别诱导欣快、寻求和厌恶状态。另一个是涉及大脑皮层、基底神经节、丘脑、上丘脑和中脑的回路，多巴胺能活动通过这些回路改变接近动机。这些模型应该有助于产生假设驱动的研究，并为理解与滥用药物和情感障碍相关的改变状态提供见解。
Dopamine neurons located in the midbrain play a role in motivation that regulates approach behavior (approach motivation). In addition, activation and inactivation of dopamine neurons regulate mood and induce reward and aversion, respectively. Accumulating evidence suggests that such motivational role of dopamine neurons is not limited to those located in the ventral tegmental area, but also in the substantia nigra. The present paper reviews previous rodent work concerning dopamine’s role in approach motivation and the connectivity of dopamine neurons, and proposes two working models: One concerns the relationship between extracellular dopamine concentration and approach motivation. High, moderate and low concentrations of extracellular dopamine induce euphoric, seeking and aversive states, respectively. The other concerns circuit loops involving the cerebral cortex, basal ganglia, thalamus, epithalamus, and midbrain through which dopaminergic activity alters approach motivation. These models should help to generate hypothesis-driven research and provide insights for understanding altered states associated with drugs of abuse and affective disorders.
登录
查看更多内容
影响因子：
25
作者：
Bock, Roland;Shin, J. Hoon;Kaplan, Alanna R.;Dobi, Alice;Markey, Eric;Kramer, Paul F.;Gremel, Christina M.;Christensen, Christine H.;Adrover, Martin F.;Alvarez, Veronica A.
通讯作者：
Alvarez, Veronica A.
影响因子：
2.9
作者：
BADIANI, A;BROWMAN, KE;ROBINSON, TE
通讯作者：
ROBINSON, TE
影响因子：
2.5
作者：
BECKSTEAD, RM
通讯作者：
BECKSTEAD, RM
影响因子：
2.5
作者：
CARTER, DA;FIBIGER, HC
通讯作者：
FIBIGER, HC
影响因子：
3.3
作者：
Bassareo, V;Di Chiara, G
通讯作者：
Di Chiara, G