Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies.
Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies.
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乳腺癌活检中S100A4，E-钙粘蛋白，α-和β-catenin的表达。
DOI：
10.1038/sj.bjc.6600624
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发表时间：
2002-11-18
影响因子：
8.8
通讯作者：
Mælandsmo, GM
中科院分区：
文献类型：
--
作者：
Pedersen, KB;Nesland, JM;Fodstad, O;Mælandsmo, GM
采用免疫组化方法检测66例乳腺癌组织中钙结合蛋白S100 A4、E-cadherin、α-catenin和β-catenin的表达，并与临床病理参数进行相关性分析。高水平的S100 A4被发现与组织学分级（P=0.030）和雌激素受体丢失（P=0.046）显著相关，但与手术和远处转移发展之间的时间间隔（P=0.51）或患者生存期（P=0.89）无关。E-cadherin表达的缺失与细胞间粘附的改变有关，与总生存期（P=0.020）和无转移期（P=0.0052）有高度显著性相关性。在多变量分析中，只有淋巴结受累是患者死亡的一个更重要的预测因素。S100 A4的表达与钙粘蛋白-连环蛋白复合物的任何单一成员之间没有发现关联，但观察到这些蛋白质中的一种或几种和S100 A4免疫反应性的表达减少的趋势（P=0.053）。总之，尽管我们的研究结果表明S100 A4表达与侵袭性肿瘤表型相关，但与总生存率无关。然而，E-cadherin表达失调具有较高的预后意义。英国癌症杂志（2002）87，1281-1286。www.bjcancer.com © 2002英国癌症研究中心
In 66 breast cancer biopsies, the expression of the Ca2+-binding protein S100A4, E-cadherin, α- and β-catenin was examined by immunohistochemistry, and the results were related to clinical and pathological parameters. High levels of S100A4 were found to significantly correlate with histological grade (P=0.030) and loss of oestrogen receptor (P=0.046), but not to the time interval between surgery and development of distant metastasis (P=0.51) or to patient survival (P=0.89). Loss of E-cadherin expression, associated with altered cell–cell adhesion, showed a highly significant association to overall survival (P=0.020) and metastasis-free period (P=0.0052). In multivariate analysis, only lymph node involvement was a more significant predictor of patient demise. No association was found between expression of S100A4 and any single member of the cadherin–catenin complex, but a trend (P=0.053) towards reduced expression of one or several of these proteins and S100A4 immunoreactivity was observed. In conclusion, although our results suggest an association between S100A4 expression and an aggressive tumour phenotype, no relationship to overall survival was found. Deregulation of E-cadherin expression, however, was of high prognostic significance. British Journal of Cancer (2002) 87, 1281–1286. doi:10.1038/sj.bjc.6600624 www.bjcancer.com © 2002 Cancer Research UK
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影响因子：
7.3
作者：
Gillett, CE;Miles, DW;Hanby, AM
通讯作者：
Hanby, AM
DOI：
10.1073/pnas.060025397
发表时间：
2000-04-11
影响因子：
11.1
作者：
Lin, SY;Xia, WY;Hung, MC
通讯作者：
Hung, MC
影响因子：
3.1
作者：
Albertazzi, E;Cajone, F;Sherbet, GV
通讯作者：
Sherbet, GV
影响因子：
56.9
作者：
TAKEICHI, M
通讯作者：
TAKEICHI, M
DOI：
10.1016/s0167-4889(98)00143-8
发表时间：
1998-12-10
影响因子：
5.1
作者：
Barraclough, R
通讯作者：
Barraclough, R