MHC class I: an unexpected role in neuronal plasticity.
MHC class I: an unexpected role in neuronal plasticity.
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DOI：
10.1016/j.neuron.2009.09.044
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发表时间：
2009-10-15
期刊：
影响因子：
16.2
通讯作者：
Shatz, Carla J.
中科院分区：
文献类型：
--
作者：
Shatz, Carla J.
为了让神经系统将经验转化为记忆和行为，突触必须发生持久的结构变化。这一要求在活动依赖性神经发育的关键时期是显而易见的，并且越来越多的证据已经确立了主要组织相容性复合体I类（MHCI）蛋白在这一过程中的惊人作用。在活动依赖性神经发育的关键时期，早期经验通过选择和加强突触子集，结合削弱和消除其他突触，塑造连接以建立成年回路。这个选择过程甚至可以在感官体验之前开始。例如，来自两只眼睛的视网膜神经节细胞（RGC）轴突最初在丘脑的外侧膝状体核（LGN）内彼此混合，随后彼此分选以实现LGN的眼睛特异性和地形有序层。关键的实验表明，适当的相关模式的神经活动所需的隔离。但是，这些早期活动模式如何促进突触重塑并最终导致持久的结构变化仍然不清楚。
For the nervous system to translate experience into memory and behavior, lasting structural change at synapses must occur. This requirement is clearly evident during critical periods of activity-dependent neural development, and accumulating evidence has established a surprising role for the major histocompatibility complex class I (MHCI) proteins in this process. During critical periods of activity-dependent neural development, early experience sculpts connections to establish adult circuits via the selection and strengthening of subsets of synapses, combined with weakening and elimination of others. This selection process can even begin well before sensory experience. For example, retinal ganglion cell (RGC) axons from the two eyes are initially intermixed with each other within the lateral geniculate nucleus (LGN) of the thalamus and later sort from each other to achieve the eye-specific and topographically ordered layers of the LGN. Key experiments indicate that appropriate correlated patterns of neural activity are required for segregation. But just how these patterns of early activity contribute to synapse remodeling and ultimately to lasting structural change remain unclear.
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