Temporal and spatial evolution of brain network topology during the first two years of life.
Temporal and spatial evolution of brain network topology during the first two years of life.
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DOI：
10.1371/journal.pone.0025278
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Gao W;Gilmore JH;Giovanello KS;Smith JK;Shen D;Zhu H;Lin W
成熟的大脑具有较高的信息传递连线效率。然而，这种高效的拓扑结构的出现过程仍然难以捉摸。通过静息状态功能磁共振成像和大量正常儿科受试者(n = 147)在脑发育关键时期(3周至2岁)的成像，揭示了脑网络拓扑的时空演变。大脑在出生后立即具有小世界拓扑结构，随后在1岁时全脑连接效率显著提高，在2岁时变得更加稳定。脑连线效率的区域性发展和功能中枢的进化表明，在生命的头两年，初级和高级认知功能有不同的发展趋势。随机错误和定向攻击的模拟表明，弹性随年龄的增加而提高。在3wk年龄组中观察到的对靶向攻击的韧性较低可能是因为在这个年龄段建立良好的远程功能连接的事实较少，这些连接的消除可能对信息传递的整体效率具有更深刻的影响。总体而言，我们的结果为早期大脑发育过程中大脑拓扑的时间和空间演变提供了新的见解。
The mature brain features high wiring efficiency for information transfer. However, the emerging process of such an efficient topology remains elusive. With resting state functional MRI and a large cohort of normal pediatric subjects (n = 147) imaged during a critical time period of brain development, 3 wk- to 2 yr-old, the temporal and spatial evolution of brain network topology is revealed. The brain possesses the small world topology immediately after birth, followed by a remarkable improvement in whole brain wiring efficiency in 1 yr olds and becomes more stable in 2 yr olds. Regional developments of brain wiring efficiency and the evolution of functional hubs suggest differential development trend for primary and higher order cognitive functions during the first two years of life. Simulations of random errors and targeted attacks reveal an age-dependent improvement of resilience. The lower resilience to targeted attack observed in 3 wk old group is likely due to the fact that there are fewer well-established long-distance functional connections at this age whose elimination might have more profound implications in the overall efficiency of information transfer. Overall, our results offer new insights into the temporal and spatial evolution of brain topology during early brain development.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.1
作者：
Afif, A.;Bouvier, R.;Mertens, P.
通讯作者：
Mertens, P.
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo