Preparation and characterization of electrospun graphene/silk fibroin conductive fibrous scaffolds
Preparation and characterization of electrospun graphene/silk fibroin conductive fibrous scaffolds
复制标题
电纺石墨烯/丝素蛋白导电纤维支架的制备及表征
DOI：
10.1039/c6ra26807b
复制
发表时间：
2017-01
期刊：
影响因子：
3.9
通讯作者：
Fan Yubo
中科院分区：
文献类型：
--
作者：
Yang Yi;Ding Xili;Zou Tongqiang;Peng Ge;Liu Haifeng;Fan Yubo
电活性支架是一种能够对生长在其上的细胞进行电刺激的材料，近年来受到越来越多的关注。在这项研究中，一个导电的纤维支架制成的丝素蛋白（SF）和石墨烯使用静电纺丝技术。所得支架的化学结构表征证实了纤维支架中石墨烯的存在。对支架的表面形貌、力学性能、电化学性能及细胞相容性进行了评价。随着石墨烯含量的增加，G/SF纤维支架的平均直径逐渐增大，直至石墨烯含量达到4%。G/SF支架在添加石墨烯的情况下表现出改善的热稳定性，这证实它们比纯SF支架更结晶。3%的G/SF纤维支架显示出改善的电活性和机械性能。体外细胞形态学、活力和增殖实验表明，它们能够支持大鼠骨髓间充质干细胞（rBMSCs）的生长和扩增。因此，本研究中的所有数据表明，3%G/SF支架可能代表在再生或工程化过程中成功支撑电活性组织的适当基质。
Electroactive scaffolds which can carry electrical stimulation to the cells growing on them have attracted more and more attention in recent years. In this study, a conductive fibrous scaffold made of silk fibroin (SF) and graphene was developed using electrospinning techniques. The chemical structural characterization of the obtained scaffolds confirmed the presence of graphene in the fibrous scaffolds. The surface morphologies, mechanical and electrochemical properties and cytocompatibility of the scaffolds were evaluated. The average diameters of the G/SF fibrous scaffolds increased with the addition of graphene until the content of graphene reached 4%. The G/SF scaffolds exhibited improved thermal stability with the addition of graphene, which confirmed that they were more crystalline than pure SF scaffolds. The 3% G/SF fibrous scaffolds showed improved electroactivity and mechanical properties. In addition, they could support the growth and expansion of rat bone mesenchymal stem cells (rBMSCs) based on cell morphology, viability and proliferation studies in vitro. Thus, all the data in this study suggested that the 3% G/SF scaffolds might represent an adequate substrate to successfully scaffold electroactive tissue during regeneration or engineering.
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影响因子：
29.4
作者：
Wang, Yu;Lee, Wong Cheng;Loh, Kian Ping
通讯作者：
Loh, Kian Ping
DOI：
10.1002/(sici)1097-4636(19980905)41:3
发表时间：
1998-09
期刊：
Journal of biomedical materials research
影响因子：
--
作者：
W. Geurtsen;F. Lehmann;W. Spahl;G. Leyhausen
通讯作者：
W. Geurtsen;F. Lehmann;W. Spahl;G. Leyhausen
具有增强机械性能的静电纺再生丝素蛋白垫
DOI：
10.1016/j.ijbiomac.2013.01.033
发表时间：
2013-05-01
影响因子：
8.2
作者：
Fan, Suna;Zhang, Yaopeng;Hu, Xuechao
通讯作者：
Hu, Xuechao
影响因子：
17.1
作者：
Li, Hui;Zeng, Xiao Cheng
通讯作者：
Zeng, Xiao Cheng
影响因子：
6.7
作者：
Mingqi Wang;Yao Wang;Yijie Chen;H. Gu
通讯作者：
Mingqi Wang;Yao Wang;Yijie Chen;H. Gu