Fabrication of Biocompatible Potassium Sodium Niobate Piezoelectric Ceramic as an Electroactive Implant.
Fabrication of Biocompatible Potassium Sodium Niobate Piezoelectric Ceramic as an Electroactive Implant.
复制标题
生物相容性铌酸钾钠压电陶瓷作为电活性植入物的制备
DOI：
10.3390/ma10040345
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发表时间：
2017-03-26
期刊：
影响因子：
--
通讯作者：
Ning C
中科院分区：
文献类型：
--
作者：
Chen W;Yu Z;Pang J;Yu P;Tan G;Ning C
天然骨中压电现象的发现吸引了广泛的研究，以模拟生物电用于各种组织再生。在这里，我们进行了实验，以建立生物相容性钾钠（KNN）陶瓷。研究了基底表面电荷对KNN陶瓷表面牛血清白蛋白（BSA）蛋白吸附和细胞增殖的影响。制得的KNN陶瓷的压电常数约为93 pC/N，相对密度约为93%。在压电常数为93 pC/N的KNN陶瓷的正表面（Ps）和负表面（Ns）上，蛋白质的吸附量均大于非极化表面（NPs）。通过MC 3 T3细胞培养和活/死细胞染色验证KNN陶瓷的生物相容性。细胞实验显示，与非极化表面（NP）相比，在正表面（Ps）和负表面（Ns）上的细胞生长增强。这些结果表明，KNN陶瓷具有很大的潜力，用于了解表面电位对细胞过程的影响，并将有利于未来的研究，设计压电材料的组织再生。
The discovery of piezoelectricity in natural bone has attracted extensive research in emulating biological electricity for various tissue regeneration. Here, we carried out experiments to build biocompatible potassium sodium niobate (KNN) ceramics. Then, influence substrate surface charges on bovine serum albumin (BSA) protein adsorption and cell proliferation on KNN ceramics surfaces was investigated. KNN ceramics with piezoelectric constant of ~93 pC/N and relative density of ~93% were fabricated. The adsorption of protein on the positive surfaces (Ps) and negative surfaces (Ns) of KNN ceramics with piezoelectric constant of ~93 pC/N showed greater protein adsorption capacity than that on non-polarized surfaces (NPs). Biocompatibility of KNN ceramics was verified through cell culturing and live/dead cell staining of MC3T3. The cells experiment showed enhanced cell growth on the positive surfaces (Ps) and negative surfaces (Ns) compared to non-polarized surfaces (NPs). These results revealed that KNN ceramics had great potential to be used to understand the effect of surface potential on cells processes and would benefit future research in designing piezoelectric materials for tissue regeneration.
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影响因子：
4.5
作者：
Cheng, Li-Qian;Zhou, Jia-Jun;Wang, Qing-Ming
通讯作者：
Wang, Qing-Ming
影响因子：
17.1
作者：
Marino, Attilio;Arai, Satoshi;Hou, Yanyan;Sinibaldi, Edoardo;Pellegrino, Mario;Chang, Young-Tae;Mazzolai, Barbara;Mattoli, Virgilio;Suzuki, Madoka;Ciofani, Gianni
通讯作者：
Ciofani, Gianni
影响因子：
56.9
作者：
BASSETT, CAL;BECKER, RO
通讯作者：
BECKER, RO
影响因子：
9.5
作者：
Espanol, Montserrat;Mestres, Gemma;Ginebra, Maria-Pau
通讯作者：
Ginebra, Maria-Pau
影响因子：
4.9
作者：
Ball, Jordan P.;Mound, Brittnee A.;Allen, Josephine B.
通讯作者：
Allen, Josephine B.