Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
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DOI：
10.1371/journal.pone.0006423
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发表时间：
2009-07-29
期刊：
影响因子：
3.7
通讯作者：
Jin L
中科院分区：
文献类型：
--
作者：
Cai XY;Wang XF;Li SL;Qian J;Qian DG;Chen F;Yang YJ;Yuan ZY;Xu J;Bai Y;Yu SZ;Jin L
长寿是一种具有遗传贡献的多因素特征，线粒体DNA (mtDNA) 多态性被发现与长寿现象有关。为了探讨 mtDNA 单倍群对极端长寿 (EL) 患病率的影响，在中国江苏省如皋市进行了一项基于人群的病例对照研究。病例对象包括 463 名年龄≥95 岁的个体（EL 组）。对照组包括从如皋市随机招募的 926 名 60-69 岁个体（老年组）和 463 名 40-49 岁个体（中年组）。我们观察到，与老年受试者（2.2%）和中年受试者（1.7%）相比，长寿受试者（0.2%）的 M9 单倍群显着减少。线性关联检验显示，中年受试者（8.6%）、老年受试者（7.2%）和长寿受试者（4.8%）的 N9 频率呈显着下降趋势（p = 0.018）。在随后按性别分层的分析中，线性关联检验显示，女性中年受试者（15.8％）、老年受试者（16.4％）和长寿受试者（21.7％）的D4频率呈显着增加趋势（p = 0.025）。相反，女性中年受试者（4.2%）、老年受试者（3.8%）和长寿受试者（1.7%）的 B4a 频率呈显着下降趋势（p = 0.045）。我们的观察结果支持线粒体 DNA 单倍群与中国人群超长寿命的关联。
Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao – a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged ≥95 yr (EL group). Control subjects include 926 individuals aged 60–69 years (elderly group) and 463 individuals aged 40–49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middle-aged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middle-aged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045). Our observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
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