Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia.
Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia.
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DOI：
10.1186/s12876-021-01659-y
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发表时间：
2021-02-18
影响因子：
2.4
通讯作者：
Uraoka T
中科院分区：
文献类型：
--
作者：
Nakamura F;Kuribayashi S;Tanaka F;Kawami N;Fujiwara Y;Iwakiri K;Kusano M;Uraoka T
功能性消化不良（FD）常合并睡眠障碍。然而，睡眠障碍如何影响FD的病理生理还不完全清楚。本研究旨在探讨FD与睡眠障碍的关系。我们在2018年12月至2019年7月期间前瞻性招募了20名患有睡眠障碍的FD患者。患者服用助眠剂4周，并在服用助眠剂前后填写问卷。采用匹兹堡睡眠质量指数（PSQI）、埃普沃思嗜睡量表（ESS）、雅典失眠量表（AIS）评定睡眠障碍的严重程度。采用改良胃食管反流病症状频率量表（mFSSG）、胃肠道症状评定量表（GSRS）和日本版患者生活质量评估量表（JPAC-QOL）评价胃肠道症状的严重程度。采用简明健康调查问卷（SF-36）评价患者的生活质量。比较了睡眠前和睡眠后问卷的用药值。在20例入组患者中，16例完成了研究方案。分别有6名、9名和1名患者接受了唑吡坦、右佐匹克隆和苏沃雷生治疗。问卷（分别为睡前/睡前用药）的中位总分如下：PSQI，10.0/8.5; ESS，12.5/5.0; AIS，10.0/4.0; mFSSG，21.0/16.0; GSRS，44.0/31.0（GSRS中的疼痛，11.0/5.0）; JPAC-QOL，26.0/15.5; SF-36，63.9/71.9。所有这些结果在睡眠药物治疗前和睡眠药物治疗后之间显示统计学显著性差异（p < 0.05）。通过给予睡眠辅助剂改善睡眠障碍导致FD患者胃肠道症状和生活质量的改善。这种效应可能与疼痛改善有关。
Functional dyspepsia (FD) is often comorbid with sleep disturbance. However, it is not fully understood how sleep disturbance affects the pathophysiology of FD. We aimed to investigate the relationship between FD and sleep disturbance. We prospectively enrolled 20 FD patients with sleep disturbance between December 2018 and July 2019. Patients took sleep aids for 4 weeks and filled out questionnaires before and after taking sleep aids. Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Athens Insomnia Scale (AIS) were used to evaluate the severity of their sleep disturbance. Modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (mFSSG), Gastrointestinal Symptom Rating Scale (GSRS), and the Japanese version of Patient Assessment of Constipation Quality of Life (JPAC-QOL) were used to evaluate the severity of GI symptoms. Short-Form 36-Item Health Survey (SF-36) was used to evaluate QOL. Pre- and post-sleep medication values of questionnaires were compared. Among 20 enrolled patients, 16 completed the study protocol. Zolpidem, eszopiclone, and suvorexant were administered to six, nine, and one patient, respectively. Each median total score of questionnaires (pre-/post-sleep medication, respectively) was as follows: PSQI, 10.0/8.5; ESS, 12.5/5.0; AIS, 10.0/4.0; mFSSG, 21.0/16.0; GSRS, 44.0/31.0 (Pain in GSRS, 11.0/5.0); JPAC-QOL, 26.0/15.5; SF-36, 63.9/71.9. All of these results showed statistically significant differences between pre- and post-sleep medication (p < 0.05). Improvement of sleep disturbance by administration of sleep aids resulted in improvement of GI symptoms and QOL in patients with FD. This effect may be related to pain modification.
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影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
4.3
作者：
Jiang, Shu-Man;Jia, Lin;Li, Wei-Dong
通讯作者：
Li, Wei-Dong
影响因子：
2.9
作者：
Jha, Lokesh K.;Fass, Ronnie;Dickman, Ram
通讯作者：
Dickman, Ram
影响因子：
6.1
作者：
GOTO, Y;TACHE, Y;NOVIN, D
通讯作者：
NOVIN, D
影响因子：
16.2
作者：
Kirchgessner, AL;Liu, MT
通讯作者：
Liu, MT