A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached.
A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached.
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DOI：
10.1007/s00394-011-0245-9
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发表时间：
2012-09
影响因子：
5
通讯作者：
Muskiet FA
中科院分区：
文献类型：
--
作者：
Luxwolda MF;Kuipers RS;Sango WS;Kwesigabo G;Dijck-Brouwer DA;Muskiet FA
与分娩时母体的脂质相比，婴儿体内的长链多不饱和脂肪酸 (LCP) 较高，这被称为生物放大。在西方国家，婴儿和母亲在哺乳期间二十二碳六烯酸 (DHA) 水平的下降表明母亲的消耗。我们研究了终生大量摄入鱼类后生物放大作用是否持续存在，以及后者是否可以防止婴儿和/或母亲 DHA 状态的产后下降。我们研究了 3 个坦桑尼亚部落，这些部落的鱼类摄入量较低（马赛：0 条/周）、中等（帕雷：2-3 条/周）和高（森格莱马：4-5 条/周）。在怀孕期间（第一个三个月 n = 14、第二个 = 103、第三个 = 88）、以及分娩时（n = 63）和产后 3 个月（n = 104）的母婴对中，测定母体 (m) 和婴儿 (i) 红细胞 (RBC) 中的 DHA 和花生四烯酸 (AA)。分娩时，所有部落的婴儿都有相似的 iRBC-AA，其高于 mRBC-AA，且与 mRBC-AA 无关。经胎盘 DHA 生物放大率高达 5.6 g% mRBC-DHA；较高的 mRBC-DHA 与“生物衰减”相关（即 iRBC-DHA < mRBC-DHA）。与分娩相比，3 个月后 mRBC-AA 较高，而 iRBC-AA 较低。与分娩相比，3 个月后 mRBC-DHA 较低，而 iRBC-DHA 较低（鱼类摄入量低）、相等（鱼类摄入量中等）和较高（鱼类摄入量高）。我们估计产后 iRBC-DHA 达到 5.9 g% 平衡，相当于整个怀孕期间 mRBC-DHA 为 6.1 g%。分娩时均匀的高 iRBC-AA 可能表明宫内婴儿 AA 状态的重要性。生物放大反映了母体 DHA 状态较低，而生物衰减可能会阻止 DHA 与 AA 的子宫内竞争。怀孕期间约 6 g% 的 mRBC-DHA 可以预测分娩时的母胎平衡，即产后 iRBC-DHA 平衡，但无法阻止产后 mRBC-DHA 下降。
Higher long-chain polyunsaturated fatty acids (LCP) in infant compared with maternal lipids at delivery is named biomagnification. The decline of infant and maternal docosahexaenoic acid (DHA) status during lactation in Western countries suggests maternal depletion. We investigated whether biomagnification persists at lifelong high fish intakes and whether the latter prevents a postpartum decline of infant and/or maternal DHA status. We studied 3 Tanzanian tribes with low (Maasai: 0/week), intermediate (Pare: 2–3/week), and high (Sengerema: 4–5/week) fish intakes. DHA and arachidonic acid (AA) were determined in maternal (m) and infant (i) erythrocytes (RBC) during pregnancy (1st trimester n = 14, 2nd = 103, 3rd = 88), and in mother–infant pairs at delivery (n = 63) and at 3 months postpartum (n = 104). At delivery, infants of all tribes had similar iRBC-AA which was higher than, and unrelated to, mRBC-AA. Transplacental DHA biomagnification occurred up to 5.6 g% mRBC-DHA; higher mRBC-DHA was associated with “bioattenuation” (i.e., iRBC-DHA < mRBC-DHA). Compared to delivery, mRBC-AA after 3 months was higher, while iRBC-AA was lower. mRBC-DHA after 3 months was lower, while iRBC-DHA was lower (low fish intake), equal (intermediate fish intake), and higher (high fish intake) compared to delivery. We estimated that postpartum iRBC-DHA equilibrium is reached at 5.9 g%, which corresponds to a mRBC-DHA of 6.1 g% throughout pregnancy. Uniform high iRBC-AA at delivery might indicate the importance of intrauterine infant AA status. Biomagnification reflects low maternal DHA status, and bioattenuation may prevent intrauterine competition of DHA with AA. A mRBC-DHA of about 6 g% during pregnancy predicts maternal–fetal equilibrium at delivery, postnatal iRBC-DHA equilibrium, but is unable to prevent a postnatal mRBC-DHA decline.
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影响因子：
3.6
作者：
CARLSON, SE;COOKE, RJ;TOLLEY, EA
通讯作者：
TOLLEY, EA
影响因子：
7.1
作者：
Carnielli, Virgilio P.;Simonato, Manuela;Cogo, Paola E.
通讯作者：
Cogo, Paola E.
影响因子：
3.6
作者：
AL, MDM;VANHOUWELINGEN, AC;HORNSTRA, G
通讯作者：
HORNSTRA, G
影响因子：
7.1
作者：
Friesen, Russell W.;Innis, Sheila M.
通讯作者：
Innis, Sheila M.
DOI：
10.1073/pnas.90.3.1073
发表时间：
1993-02-01
影响因子：
11.1
作者：
CARLSON, SE;WERKMAN, SH;TOLLEY, EA
通讯作者：
TOLLEY, EA