The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.
The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.
复制标题
DOI：
10.1037/a0030855
复制
发表时间：
2013-01
期刊：
影响因子：
2.4
通讯作者：
Fisher, G. G.
中科院分区：
文献类型：
--
作者：
Brainerd, C. J.;Reyna, V. F.;Petersen, R. C.;Smith, G. E.;Kenney, A. E.;Gross, C. J.;Taub, E. S.;Plassman, B. L.;Fisher, G. G.
载脂蛋白E （APOE）基因型的ε4等位基因是最被广泛接受的阿尔茨海默氏痴呆（AD）的遗传危险因素，但关于它是否是AD前驱症状轻度认知障碍（MCI）的危险因素的研究结果一直不一致。在一项前瞻性纵向设计中，我们调查了(a)正常ε4携带者是否比非携带者更频繁地过渡到MCI和其他形式的无痴呆神经认知障碍（CIND），以及(b) ε4携带者是否比非携带者更频繁地从MCI和其他形式的CIND过渡到AD。ε4等位基因的频率在老年人中进行了研究（平均年龄在50到70岁之间），这些老年人参加了由密歇根大学主持的美国卫生与公众服务部、国家卫生研究院、国家老龄健康与退休研究所的老龄化、人口统计学和记忆研究（ADAMS）的两波或两波以上的神经心理测试和诊断。ε4与特定类型CIND和痴呆的纵向过渡之间的关联可以通过该数据集确定。Epsilon 4增加了从正常功能到MCI的进展率（58%的新诊断为携带者），但没有增加到其他形式的CIND。由MCI或其他形式的CIND进展为AD的比率没有增加ε 4。结果支持ε4是从正常功能过渡到轻度认知障碍的危险因素，而不是随后过渡到AD的危险因素的假设。在ADAMS样本中，ε 4在AD个体中升高的原因是因为它在MCI个体中已经升高，MCI个体是新AD诊断的主要来源。
The ε4 allele of the apolipoprotein E (APOE) genotype is the most widely accepted genetic risk factor for Alzheimer’s dementia (AD), but findings on whether it is a risk factor for the AD prodrome, mild cognitive impairment (MCI), have been inconsistent. In a prospective longitudinal design, we investigated (a) whether transitions to MCI and other forms of neurocognitive impairment without dementia (CIND) are more frequent among normal ε4 carriers than among noncarriers and (b) whether subsequent transitions to AD from MCI and from other forms of CIND are more frequent among ε4 carriers than among noncarriers. The frequency of the ε4 allele was studied in older adults (mean age > 70), who had participated in two or more waves of neuropsychological testing and diagnosis in the Aging, Demographics, and Memory Study (ADAMS) of the United States Department of Health and Human Services, National Institutes of Health, National Institute on Aging’s Health and Retirement Study, conducted by the University of Mchigan. The association between ε4 and longitudinal transitions to specific types of CIND and dementia can be determined with this data set. Epsilon 4 increased the rate of progression from normal functioning to MCI (58% of new diagnoses were carriers) but not to other forms of CIND. The rate of progression to AD from MCI or from other forms of CIND was not increased by ε 4. The results support the hypothesis that ε4 is a risk factor for transitions from normal functioning to MCI but not for subsequent transitions to AD. In the ADAMS sample, the reason ε 4 is elevated in AD individuals is because it is already elevated in MCI individuals, who are the primary source of new AD diagnoses.
登录
查看更多内容
影响因子：
5.7
作者：
Langa, KM;Plassman, BL;Willis, RJ
通讯作者：
Willis, RJ
DOI：
10.1076/jcen.24.6.720.8397
发表时间：
2002-09-01
影响因子：
2.2
作者：
Collie, A;Maruff, P;Currie, J
通讯作者：
Currie, J
影响因子：
--
作者：
Devanand, DP;Pelton, GH;Mayeux, R
通讯作者：
Mayeux, R
影响因子：
5.7
作者：
Plassman, B. L.;Langa, K. M.;Wallace, R. B.
通讯作者：
Wallace, R. B.
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH