Effects of inversion time on inversion recovery prepared ultrashort echo time (IR-UTE) imaging of bound and pore water in cortical bone.
Effects of inversion time on inversion recovery prepared ultrashort echo time (IR-UTE) imaging of bound and pore water in cortical bone.
复制标题
反转时间对恢复的反演恢复的影响，制备了皮质骨中结合和孔隙水的超短回声时间（IR-ut）成像。
DOI：
10.1002/nbm.3228
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发表时间：
2015-01
影响因子：
2.9
通讯作者：
Du, Jiang
中科院分区：
文献类型：
--
作者：
Li, Shihong;Ma, Lanqing;Chang, Eric Y.;Shao, Hongda;Chen, Jun;Chung, Christine B.;Bydder, Graeme M.;Du, Jiang
水以不同的结合状态存在于皮质骨中。在这项研究中，我们旨在研究反转时间（TI）对皮质骨中结合水和孔隙水信号的影响，使用绝热反转恢复制备的超短回波时间（IR-UTE）序列在临床3T扫描仪上。本研究共采集了10个牛胫骨中轴样本和4个人胫骨中轴样本。对每个皮质样本进行UTE和IR-UTE序列成像，TR为300 ms， ti为10 ~ 240 ms。5名健康志愿者也用同样的序列进行了成像。采用单组分和双组分模型计算T2*组分及短组分和长组分的相对分数。IR-UTE序列显示皮质骨信号的双组分行为，除了在80 ms左右的TI中只看到短T2*组分，并观察到单指数衰减模式。使用IR-UTE序列进行体内成像，可以提供高对比度的图像，直接显示束缚水，减少T2长肌肉和脂肪的信号。我们的初步结果表明，通过IR-UTE序列和适当的TI可以选择性地消除孔隙水成分，从而允许使用临床MR扫描仪对体内皮质骨中的结合水成分进行选择性成像。
Water is present in cortical bone in different binding states. In this study we aimed to investigate the effects of inversion time (TI) on the signal from bound and pore water in cortical bone using an adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequence on a clinical 3T scanner. In total ten bovine midshaft samples and four human tibial midshaft samples were harvested for this study. Each cortical sample was imaged with the UTE and IR-UTE sequences with a TR of 300 ms and a series of TIs ranging from 10 to 240 ms. Five healthy volunteers were also imaged with the same sequence. Single- and bi-component models were utilized to calculate the T2* and relative fractions of short and long T2* components. Bi-component behavior of the signal from cortical bone was seen with the IR-UTE sequence except with a TI of around 80 ms where the short T2* component alone were seen and a mono-exponential decay pattern was observed. In vivo imaging with the IR-UTE sequence provided high contrast-to-noise images with direct visualization of bound water and reduced signal from long T2 muscle and fat. Our preliminary results demonstrate that selective nulling of the pore water component can be achieved with the IR-UTE sequence with an appropriate TI, allowing selective imaging of the bound water component in cortical bone in vivo using clinical MR scanners.
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影响因子：
4.1
作者：
Biswas, Reni;Bae, Won;Diaz, Eric;Masuda, Koichi;Chung, Christine B.;Bydder, Graeme M.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
4.1
作者：
Cao, Haihui;Nazarian, Ara;Ackerman, Jerome L.;Snyder, Brian D.;Rosenberg, Andrew E.;Nazarian, Rosalynn M.;Hrovat, Mirko I.;Dai, Guangping;Mintzopoulos, Dionyssios;Wu, Yaotang
通讯作者：
Wu, Yaotang
影响因子：
3.3
作者：
Qian, Yongxian;Williams, Ashley A.;Chu, Constance R.;Boada, Fernando E.
通讯作者：
Boada, Fernando E.
影响因子：
2.8
作者：
Wang, XD;Ni, QW
通讯作者：
Ni, QW
影响因子：
4.2
作者：
LEES, S
通讯作者：
LEES, S