Circadian Rhythms in Resting Metabolic Rate Account for Apparent Daily Rhythms in the Thermic Effect of Food.
Circadian Rhythms in Resting Metabolic Rate Account for Apparent Daily Rhythms in the Thermic Effect of Food.
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静息代谢率的昼夜节律解释了食物热效应的明显日节律。
DOI：
10.1210/clinem/dgab654
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发表时间：
2022-01-18
期刊：
影响因子：
--
通讯作者：
Johnstone AM
中科院分区：
文献类型：
--
作者：
Ruddick-Collins LC;Flanagan A;Johnston JD;Morgan PJ;Johnstone AM
食物热效应（TEF）的每日变化被普遍报道并被认为是晚食体重增加的一个影响因素。然而，在计算与一天中不同时间进食相关的 TEF 时，静息代谢率 (RMR) 的潜在昼夜节律变化是一个被忽视的因素。这项工作旨在确定计算 TEF 的方法是否会导致所报告的 TEF 每日变化现象。在临床研究单位对 14 名超重至肥胖但其他方面健康的人进行了超过 15.5 小时的静息和餐后能量消耗 (EE) 测量。使用标准方法（高于基线和餐前 RMR 测量）计算早餐、午餐和晚餐的 TEF，并与结合昼夜节律 RMR 的方法进行比较，其中 RMR 源自正弦曲线模型，TEF 是在不断变化的 RMR 之上计算的。主要结果指标是通过不同方法计算的早餐、午餐和晚餐的 TEF。计算高于餐前测量的 RMR 的 TEF 的标准方法显示，早晨 TEF (60.8 kcal ± 5.6)（平均值± SEM）比午餐时 TEF (36.3 kcal ± 8.4) 高 1.6 倍，比晚餐 TEF (25.2 kcal ± 9.6) 高 2.4 倍(P = .022)。然而，对模型昼夜节律 RMR 进行调整后，早餐 (54.1 kcal ± 30.8)、午餐 (49.5 kcal ± 29.4) 和晚餐 (49.1 kcal ± 25.7) 之间的任何差异均无效 (P = .680)。早上和晚上 TEF 的差异可以通过潜在的昼夜节律静息 EE 来解释，该昼夜节律静息 EE 与饮食的急性影响无关。
Daily variation in the thermic effect of food (TEF) is commonly reported and proposed as a contributing factor to weight gain with late eating. However, underlying circadian variability in resting metabolic rate (RMR) is an overlooked factor when calculating TEF associated with eating at different times of the day. This work aimed to determine whether methodological approaches to calculating TEF contribute to the reported phenomena of daily variation in TEF. Fourteen overweight to obese but otherwise healthy individuals had their resting and postprandial energy expenditure (EE) measured over 15.5 hours at a clinical research unit. TEF was calculated for breakfast, lunch, and dinner using standard methods (above a baseline and premeal RMR measure) and compared to a method incorporating a circadian RMR by which RMR was derived from a sinusoid curve model and TEF was calculated over and above the continuously changing RMR. Main outcome measures were TEF at breakfast, lunch, and dinner calculated by different methods. Standard methods of calculating TEF above a premeal measured RMR showed that morning TEF (60.8 kcal ± 5.6) (mean ± SEM) was 1.6 times greater than TEF at lunch (36.3 kcal ± 8.4) and 2.4 times greater than dinner TEF (25.2 kcal ± 9.6) (P = .022). However, adjusting for modeled circadian RMR nullified any differences between breakfast (54.1 kcal ± 30.8), lunch (49.5 kcal ± 29.4), and dinner (49.1 kcal ± 25.7) (P = .680). Differences in TEF between morning and evening can be explained by the underlying circadian resting EE, which is independent of an acute effect of eating.
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影响因子：
3.6
作者：
Ruddick-Collins，Leonie C.;King，Neil A.;Wood，Rachel E.
通讯作者：
Wood，Rachel E.
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
DOI：
10.1002/oby.21189
发表时间：
2015-10
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Morris CJ;Garcia JI;Myers S;Yang JN;Trienekens N;Scheer FA
通讯作者：
Scheer FA
影响因子：
4.4
作者：
Baehr, EK;Revelle, W;Eastman, CI
通讯作者：
Eastman, CI
影响因子：
6.9
作者：
Jakubowicz, Daniela;Barnea, Maayan;Froy, Oren
通讯作者：
Froy, Oren