Indirect measures of cigarette use: expired-air carbon monoxide versus plasma thiocyanate.

Indirect measures of cigarette use: expired-air carbon monoxide versus plasma thiocyanate.
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香烟使用的间接测量:呼出空气一氧化碳与血浆硫氰酸盐。

DOI:
10.1016/0091-7435(84)90045-8
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发表时间:
1984
影响因子:
5.1
通讯作者:
Farquhar,JW
Farquhar,JW
中科院分区:
医学2区
文献类型:
--
作者:
Fortmann,SP;Rogers,T;Vranizan,K;Haskell,WL;Solomon,DS;Farquhar,JW

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在横断面研究和戒烟研究中,香烟使用的间接生化测量在确认吸烟状态方面都是有价值的。这项研究比较了来自斯坦福五城项目基线调查的2237名成年人(18-74岁)的代表性人群样本中的两种生化标志物,即过期空气中的一氧化碳(CO)和血浆硫氰酸盐(SCN)。自我报告吸烟者的CO和SCN都明显高于非吸烟者,并且与每天吸烟的数量密切相关。与自我报告相比,CO似乎比SCN更敏感和特异性,CO对非吸烟者、经常吸烟者和轻度吸烟者(每天吸烟<9支)的错误分类数量明显少于SCN。CO和SCN结合起来比单独区分吸烟者和非吸烟者更好。对于不规律吸烟者(48小时内不吸烟),这两项生化指标都不可靠。尽管其代谢半衰期短得多,但在本横断面研究中,一氧化碳是比SCN更好的香烟使用指标。CO通常比SCN测量更简单,成本更低,在一些戒烟研究中,CO可能是吸烟状况的较好间接测量方法。
Indirect, biochemical measures of cigarette use are valuable in confirming smoking status in both cross-sectional and cessation studies. This study compares two such biochemical markers, expired-air carbon monoxide (CO) and plasma thiocyanate (SCN), in a representative population sample of 2,237 adults (ages 18–74) from the baseline survey of the Stanford Five City Project. CO and SCN are both significantly higher in self-reported smokers than in nonsmokers and correlate well with number of cigarettes smoked per day. CO appears to be more sensitive and specific than SCN in comparison to self-report, and CO misclassifies a significantly smaller number of nonsmokers, regular smokers, and light smokers (<9 cigarettes per day) than does SCN. Together, CO and SCN better classify smokers and nonsmokers than do either alone. Neither biochemical is a reliable indicator in irregular smokers (no cigarettes in past 48 hr). Despite its much shorter metabolic halflife, CO is a better indicator of cigarette use than is SCN in this cross-sectional study. CO is generally simpler and less expensive to measure than is SCN, and CO may be a preferable indirect measure of smoking status in some studies of smoking cessation.
微扩散法测定全血中氰化物及其在氰化物向硫氰酸盐转化研究中的应用
DOI: 10.1093/clinchem/19.5.466
发表时间: 1973
期刊: Clinical chemistry
影响因子: 9.3
作者:
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通讯作者: G. Fell
DOI: 10.1093/clinchem/18.9.996
发表时间: 1972-09
期刊: Clinical chemistry
影响因子: 9.3
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DOI: 10.1136/bmj.2.6146.1185
发表时间: 1978-01-01
影响因子: --
作者:
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碳氧血红蛋白和血清硫氰酸盐测定作为吸烟指标的比较。
DOI: 10.2105/ajph.70.3.284
发表时间: 1980
影响因子: 12.7
作者:
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呼出空气一氧化碳和血清硫氰酸盐作为香烟暴露的客观指标。
DOI: 10.2105/ajph.67.6.545
发表时间: 1977
影响因子: 12.7
作者:
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通讯作者: S. Hulley