Hippocampal place-cell sequences depict future paths to remembered goals.
Hippocampal place-cell sequences depict future paths to remembered goals.
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有效的导航需要计划延伸的路线到记住的目标位置。海马位置细胞已被提出在导航规划中发挥作用，但一直缺乏直接的证据。在这里，我们表明，目标导向的导航之前，在一个开放的竞技场，海马体产生简短的序列编码空间轨迹强烈偏向于从受试者的当前位置的进展到一个已知的目标位置。这些序列可以预测未来的行为，即使在起始位置和目标位置的特定组合是新的情况下。这些结果表明，海马序列事件先前在线性约束的环境中表征为“重放”，也能够支持目标导向的，自动寻找机制，该机制识别重要的地方和相关的行为路径，在特定的时间，当需要记忆检索时，并以一种可用于控制随后的导航行为的方式。
Effective navigation requires planning extended routes to remembered goal locations. Hippocampal place cells have been proposed to play a role in navigational planning but direct evidence has been lacking. Here, we show that prior to goal-directed navigation in an open arena, the hippocampus generates brief sequences encoding spatial trajectories strongly biased to progress from the subject’s current location to a known goal location. These sequences predict immediate future behavior, even in cases when the specific combination of start and goal locations is novel. These results suggest that hippocampal sequence events previously characterized in linearly constrained environments as ‘replay’ are also capable of supporting a goal-directed, trajectory-finding mechanism, which identifies important places and relevant behavioral paths, at specific times when memory retrieval is required, and in a manner which could be used to control subsequent navigational behavior.
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