Regeneration of articular cartilage in healer and non-healer mice.
Regeneration of articular cartilage in healer and non-healer mice.
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DOI：
10.1016/j.matbio.2014.08.011
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发表时间：
2014-10
期刊：
影响因子：
6.9
通讯作者：
Sandell, Linda J.
中科院分区：
文献类型：
--
作者：
Rai, Muhammad Farooq;Sandell, Linda J.
关键词：
哺乳动物在成年后很少再生它们丢失或受伤的组织。MRL/MpJ小鼠株最初被认为可以治愈全层耳伤，现在它代表了哺乳动物伤口再生的经典例子，因为它可以治愈一系列损伤，如皮肤和心脏伤口，神经损伤和膝关节软骨病变。除了MRL/MpJ之外，其他一些小鼠品系，如LG/J （MRL/MpJ的亲本）和LGXSM-6（由LG/J和SM/J小鼠品系杂交而成），现在已经被认为具有与MRL/MpJ小鼠相似甚至优于MRL/MpJ小鼠的关节软骨和耳部伤口损伤的再生/愈合能力。虽然再生潜能的一些机制已经开始出现，但一整套的生物学过程和途径仍然需要阐明。我们最近的工作利用一组治疗性和非治疗性小鼠品系，为可能与治疗潜力相关的基因提供了一些见解。未来的机制研究可以帮助寻找再生医学的圣杯。这篇综述强调了特定小鼠品系对关节软骨的再生能力，特别是从其他身体组织中得到的经验教训。
Mammals rarely regenerate their lost or injured tissues into adulthood. MRL/MpJ mouse strain initially identified to heal full-thickness ear wounds now represents a classical example of mammalian wound regeneration since it can heal a spectrum of injuries such as skin and cardiac wounds, nerve injuries and knee articular cartilage lesions. In addition to MRL/MpJ, a few other mouse strains such as LG/J (a parent of MRL/MpJ) and LGXSM-6 (arising from an intercross between LG/J and SM/J mouse strains) have now been recognized to possess regenerative/healing abilities for articular cartilage and ear wound injuries that are similar, if not superior, to MRL/MpJ mice. While some mechanisms underlying regenerative potential have been begun to emerge, a complete set of biological processes and pathways still needs to be elucidated. Using a panel of healer and non-healer mouse strains, our recent work has provided some insights into the genes that could potentially be associated with healing potential. Future mechanistic studies can help seek the Holy Grail of regenerative medicine. This review highlights the regenerative capacity of selected mouse strains for articular cartilage, in particular, and lessons from other body tissues, in general.
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影响因子：
--
作者：
Lewis, John S., Jr.;Furman, Bridgette D.;Zeitler, Evan;Huebner, Janet L.;Kraus, Virginia B.;Guilak, Farshid;Olson, Steven A.
通讯作者：
Olson, Steven A.
影响因子：
2.9
作者：
Colwell, AS;Krummel, TM;Lorenz, HP
通讯作者：
Lorenz, HP
影响因子：
2.9
作者：
Chadwick, Robert B.;Bu, Liming;Baylink, David J.
通讯作者：
Baylink, David J.
DOI：
10.1073/pnas.95.20.11792
发表时间：
1998-09-29
影响因子：
11.1
作者：
McBrearty, BA;Clark, LD;Heber-Katze, E
通讯作者：
Heber-Katze, E
影响因子：
5.2
作者：
Galvin, Katherine E.;Ye, Hong;Wetmore, Cynthia
通讯作者：
Wetmore, Cynthia